-transparent.png){kind=logo}
1. We studied the effects of a calcium antagonist diltiazem, as well as diazepam and phenytoin on hyperthermia induced seizures in unrestrained 15 day-old rats. 2. Saline injected animals exposed to an ambient temperature of 40 degrees C showed a gradual increase in body temperature reaching a maximum of 42 +/- 0.1 degree C at 50 min. 3. At this time all rats pups had generalized seizures. 4. Similar results were obtained when the animals were pretreated with phenytoin (100% showed seizures). 5. Animals receiving diltiazem had a temperature of 41.5 +/- 0.1 degree C at 90 min of exposure to 40 degrees C environment. 6. However, diltiazem completely prevented seizures. 7. The rats treated with diazepam showed lower temperature than in saline, diltiazem and phenytoin groups and no seizures were observed in this experimental group.
M L Laorden, and
E Carrillo, and
F S Miralles, and
M M Puig
February 1984,
Epilepsia,
M L Laorden, and
E Carrillo, and
F S Miralles, and
M M Puig
August 1981,
Science (New York, N.Y.),
M L Laorden, and
E Carrillo, and
F S Miralles, and
M M Puig
February 2020,
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience,
M L Laorden, and
E Carrillo, and
F S Miralles, and
M M Puig
January 1985,
Epilepsia,
M L Laorden, and
E Carrillo, and
F S Miralles, and
M M Puig
October 1994,
Anesthesia and analgesia,
M L Laorden, and
E Carrillo, and
F S Miralles, and
M M Puig
August 2015,
Brain and behavior,
M L Laorden, and
E Carrillo, and
F S Miralles, and
M M Puig
May 2009,
Stress (Amsterdam, Netherlands),
M L Laorden, and
E Carrillo, and
F S Miralles, and
M M Puig
October 2013,
Epilepsy research,
M L Laorden, and
E Carrillo, and
F S Miralles, and
M M Puig
January 2011,
Proceedings of the Western Pharmacology Society,
M L Laorden, and
E Carrillo, and
F S Miralles, and
M M Puig
January 1996,
Neurotoxicology,
