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The effects of systemically injected caerulein, a cholecystokinin octapeptide analogue, on GABA content and turnover have been studied in various regions of rat brain. Caerulein decreased GABA levels in the nucleus accumbens, tuberculum olfactorium and substantia nigra and diminished GABA turnover rates in the striatum, nucleus accumbens and substantia nigra, as estimated from the rate of GABA accumulation after inhibition of GABA transaminase by aminooxyacetic acid (AOAA). These results indicate the effect of caerulein on the utilization of GABA in specific cerebral regions and suggest that the GABAergic system is involved in the mechanism of action of peripherally administered caerulein.
K Nakamura, and
T Matsumoto, and
M Hirano, and
H Uchimura
January 2009,
Neurochemistry international,
K Nakamura, and
T Matsumoto, and
M Hirano, and
H Uchimura
July 2009,
Medicinal chemistry (Shariqah (United Arab Emirates)),
K Nakamura, and
T Matsumoto, and
M Hirano, and
H Uchimura
January 2006,
Neurochemical research,
K Nakamura, and
T Matsumoto, and
M Hirano, and
H Uchimura
January 1988,
Neurochemistry international,
K Nakamura, and
T Matsumoto, and
M Hirano, and
H Uchimura
October 1979,
Journal of neurochemistry,
K Nakamura, and
T Matsumoto, and
M Hirano, and
H Uchimura
April 1975,
Journal of neurochemistry,
K Nakamura, and
T Matsumoto, and
M Hirano, and
H Uchimura
September 1994,
Neurochemical research,
K Nakamura, and
T Matsumoto, and
M Hirano, and
H Uchimura
January 1979,
Naunyn-Schmiedeberg's archives of pharmacology,
K Nakamura, and
T Matsumoto, and
M Hirano, and
H Uchimura
November 1988,
Pharmacology, biochemistry, and behavior,
K Nakamura, and
T Matsumoto, and
M Hirano, and
H Uchimura
June 1988,
Brain research,
