Biomaterial Database

Ischemic left ventricular dysfunction assessed on ECG-gated thallium-201 myocardial perfusion images. 1990

G A Hurwitz, and N R Laurin, and J E Powe, and A A Driedger, and A C MacDonald

Department of Diagnostic Radiology/Nuclear Medicine, University of Western Ontario, London.

Ischemic dysfunction of the left ventricle can be suggested by ancillary data derived from thallium-201 myocardial perfusion images. In this study, qualitative and quantitative assessments of global and segmental contraction derived from ECG-gated left anterior oblique images were analyzed to define more precisely transient ischemic hypokinesis. Immediate (4 mins post stress) and delayed (2 to 4 h) images were compared in 200 patients; 165 had coronary angiography and 35 had a low probability of coronary artery disease based on pretest and test outcome variables. For both immediate and delayed images, a quantitative index of left ventricular contraction (derived from the time-activity curve of the left ventricular cavity and validated in a previous study), correlated well with contrast ventriculography scores. The index derived from the immediate image also was related to the severity/extent of coronary artery lesions and to thallium-201 lung uptake. The ratio of indices (immediate/delayed) was depressed (P less than 0.001) in patients with two or three critically diseased vessels, and reflected the qualitative assessment of stress-induced dysfunction on cinematic images. These data suggest that the quantitative index derived from ECG-gated perfusion scans may be a valuable indicator of stress-induced ventricular contractile dysfunction.

UI	MeSH Term	Description	Entries
D009200	Myocardial Contraction	Contractile activity of the MYOCARDIUM.	Heart Contractility,Inotropism, Cardiac,Cardiac Inotropism,Cardiac Inotropisms,Contractilities, Heart,Contractility, Heart,Contraction, Myocardial,Contractions, Myocardial,Heart Contractilities,Inotropisms, Cardiac,Myocardial Contractions
D003327	Coronary Disease	An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.	Coronary Heart Disease,Coronary Diseases,Coronary Heart Diseases,Disease, Coronary,Disease, Coronary Heart,Diseases, Coronary,Diseases, Coronary Heart,Heart Disease, Coronary,Heart Diseases, Coronary
D005082	Physical Exertion	Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.	Physical Effort,Effort, Physical,Efforts, Physical,Exertion, Physical,Exertions, Physical,Physical Efforts,Physical Exertions
D006352	Heart Ventricles	The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.	Cardiac Ventricle,Cardiac Ventricles,Heart Ventricle,Left Ventricle,Right Ventricle,Left Ventricles,Right Ventricles,Ventricle, Cardiac,Ventricle, Heart,Ventricle, Left,Ventricle, Right,Ventricles, Cardiac,Ventricles, Heart,Ventricles, Left,Ventricles, Right
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013318	Stroke Volume	The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.	Ventricular Ejection Fraction,Ventricular End-Diastolic Volume,Ventricular End-Systolic Volume,Ejection Fraction, Ventricular,Ejection Fractions, Ventricular,End-Diastolic Volume, Ventricular,End-Diastolic Volumes, Ventricular,End-Systolic Volume, Ventricular,End-Systolic Volumes, Ventricular,Fraction, Ventricular Ejection,Fractions, Ventricular Ejection,Stroke Volumes,Ventricular Ejection Fractions,Ventricular End Diastolic Volume,Ventricular End Systolic Volume,Ventricular End-Diastolic Volumes,Ventricular End-Systolic Volumes,Volume, Stroke,Volume, Ventricular End-Diastolic,Volume, Ventricular End-Systolic,Volumes, Stroke,Volumes, Ventricular End-Diastolic,Volumes, Ventricular End-Systolic
D013794	Thallium Radioisotopes	Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.	Radioisotopes, Thallium
D015637	Gated Blood-Pool Imaging	Radionuclide ventriculography where scintigraphic data is acquired during repeated cardiac cycles at specific times in the cycle, using an electrocardiographic synchronizer or gating device. Analysis of right ventricular function is difficult with this technique; that is best evaluated by first-pass ventriculography (VENTRICULOGRAPHY, FIRST-PASS).	Angiography, Gated Radionuclide,Equilibrium Radionuclide Angiography,Equilibrium Radionuclide Ventriculography,Gated Blood-Pool Scintigraphy,Gated Equilibrium Blood-Pool Scintigraphy,Radionuclide Angiography, Gated,Radionuclide Ventriculography, Gated,Scintigraphy, Equilibrium,Ventriculography, Equilibrium Radionuclide,Ventriculography, Gated Radionuclide,Blood-Pool Scintigraphy,Equilibrium Radionuclide Angiocardiography,Gated Equilibrium Blood Pool Scintigraphy,Angiocardiographies, Equilibrium Radionuclide,Angiocardiography, Equilibrium Radionuclide,Angiographies, Equilibrium Radionuclide,Angiographies, Gated Radionuclide,Angiography, Equilibrium Radionuclide,Blood Pool Scintigraphy,Blood-Pool Imaging, Gated,Blood-Pool Imagings, Gated,Blood-Pool Scintigraphies,Blood-Pool Scintigraphies, Gated,Blood-Pool Scintigraphy, Gated,Equilibrium Radionuclide Angiocardiographies,Equilibrium Radionuclide Angiographies,Equilibrium Radionuclide Ventriculographies,Equilibrium Scintigraphies,Equilibrium Scintigraphy,Gated Blood Pool Imaging,Gated Blood Pool Scintigraphy,Gated Blood-Pool Imagings,Gated Blood-Pool Scintigraphies,Gated Radionuclide Angiographies,Gated Radionuclide Angiography,Gated Radionuclide Ventriculographies,Gated Radionuclide Ventriculography,Imaging, Gated Blood-Pool,Imagings, Gated Blood-Pool,Radionuclide Angiocardiographies, Equilibrium,Radionuclide Angiocardiography, Equilibrium,Radionuclide Angiographies, Equilibrium,Radionuclide Angiographies, Gated,Radionuclide Angiography, Equilibrium,Radionuclide Ventriculographies, Equilibrium,Radionuclide Ventriculographies, Gated,Radionuclide Ventriculography, Equilibrium,Scintigraphies, Blood-Pool,Scintigraphies, Equilibrium,Scintigraphies, Gated Blood-Pool,Scintigraphy, Blood-Pool,Scintigraphy, Gated Blood-Pool,Ventriculographies, Equilibrium Radionuclide,Ventriculographies, Gated Radionuclide