Biomaterial Database

Flow injection chemiluminescence determination of naphazoline hydrochloride in pharmaceuticals. 2014

Mortaza Iranifam, and Mohammad H Sorouraddin

Department of Chemistry, Faculty of Science, University of Maragheh, Maragheh, Iran.

A simple and sensitive flow injection chemiluminescence (FI-CL) method was developed for the determination of naphazoline hydrochloride (NPZ). The method is based on the enhancing effect of NPZ on the weak CL signal from the reaction of KIO4 with H2 O2 . Experimental parameters that affected the CL signal, including the pH of the KIO4 solution, concentrations of KIO4 , H2 O2 and disodium-EDTA and flow rate were optimized. Under the optimum conditions, the increment of CL intensity was linearly proportional to the concentration of NPZ in the range 5.0 × 10(-6) to 70 × 10(-6) mol/L. The detection limit was 1.0 × 10(-6) mol/L and the relative standard deviation for 50 × 10(-6) mol/L NPZ solution was 2.8% (n = 11). In addition, a high throughput of 120 samples/h was achieved. The utility of this method was demonstrated by determining NPZ in pharmaceuticals.

UI	MeSH Term	Description	Entries
D009278	Naphazoline	An adrenergic vasoconstrictor agent used as a decongestant.	AK-Con,Afazol Grin,Albalon,All Clear,Clear Eyes,Colirio Alfa,Idril,Miraclar,Nafazair,Naphazoline Hydrochloride,Naphazoline Monohydrochloride,Naphazoline Nitrate,Naphcon,Naphcon Forte,Optazine,Privin,Privine,Proculin,Siozwo,Tele-Stulln,VasoNit,Vasoclear,Vasocon,Vasocon Regular,Vasoconstrictor Pensa,AK Con,Hydrochloride, Naphazoline,Monohydrochloride, Naphazoline,Nitrate, Naphazoline,Pensa, Vasoconstrictor,Tele Stulln
D006861	Hydrogen Peroxide	A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.	Hydrogen Peroxide (H2O2),Hydroperoxide,Oxydol,Perhydrol,Superoxol,Peroxide, Hydrogen
D006863	Hydrogen-Ion Concentration	The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH	pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations
D017022	Flow Injection Analysis	The analysis of a chemical substance by inserting a sample into a carrier stream of reagent using a sample injection valve that propels the sample downstream where mixing occurs in a coiled tube, then passes into a flow-through detector and a recorder or other data handling device.	Analysis, Flow Injection,Analyses, Flow Injection,Flow Injection Analyses,Injection Analyses, Flow,Injection Analysis, Flow
D049449	Luminescence	Emission of LIGHT when ELECTRONS return to the electronic ground state from an excited state and lose the energy as PHOTONS. It is sometimes called cool light in contrast to INCANDESCENCE. LUMINESCENT MEASUREMENTS take advantage of this type of light emitted from LUMINESCENT AGENTS.	Luminescence, Physical,Chemiluminescence,Chemiluminescence, Physical,Physical Chemiluminescence,Physical Luminescence