BIOMAT Database Logo BIOMAT Database Logo

A noninvasive screening of systemic reactive (secondary) AA amyloidosis, based on reduced amyloid degrading activity of amyloidotic serum. 1990

M Ravid, and Y Greenman, and J Shapira, and I Kedar
Department of Medicine, Meir General Hospital, Kfar Saba, Israel.

Standardization of the measurement of amyloid degrading activity (ADA) by diffusion of serum in amyloid-impregnated agar plates may either indicate or exclude with reasonable certainty the presence of systemic AA amyloidosis. In certain cases, it may obviate the need for a diagnostic biopsy. The sera of 38 patients with systemic amyloidosis were tested and compared with sera of 38 controls matched for age, serum creatinine and albumin blood levels, and with sera of 48 additional controls with the same basic diseases as the amyloidotic patients but without amyloidosis. The difference between ADA of amyloidotic and control patients was significant, with no overlap in the range of activity between the two groups. A positive correlation was found between ADA and serum albumin concentration in the nonamyloidotic matched controls but not in patients with amyloidosis. Our data do not support the view that the decline in ADA of sera of amyloidotic patients is due to hypoalbuminemia.

UI MeSH Term Description Entries
D008297 Male Males
D008403 Mass Screening Organized periodic procedures performed on large groups of people for the purpose of detecting disease. Screening,Mass Screenings,Screening, Mass,Screenings,Screenings, Mass
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000273 Adipose Tissue Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white. Fatty Tissue,Body Fat,Fat Pad,Fat Pads,Pad, Fat,Pads, Fat,Tissue, Adipose,Tissue, Fatty
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000682 Amyloid A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease. Amyloid Fibril,Amyloid Fibrils,Amyloid Substance,Fibril, Amyloid,Fibrils, Amyloid,Substance, Amyloid
D000686 Amyloidosis A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits. Amyloidoses

Related Publications

M Ravid, and Y Greenman, and J Shapira, and I Kedar
Mechanism of reduced amyloid-A-degrading activity in serum of patients with secondary amyloidosis.
July 1982, Lancet (London, England),
M Ravid, and Y Greenman, and J Shapira, and I Kedar
Serum esterase activity in reactive systemic amyloidosis and its relation to amyloid A degrading activity.
November 1984, The Journal of laboratory and clinical medicine,
M Ravid, and Y Greenman, and J Shapira, and I Kedar
[Systemic secondary AA amyloidosis].
April 2015, Medicina clinica,
M Ravid, and Y Greenman, and J Shapira, and I Kedar
Reduced amyloid-A-degrading activity in serum in amyloidosis associated with rheumatoid arthritis.
February 1982, British medical journal (Clinical research ed.),
M Ravid, and Y Greenman, and J Shapira, and I Kedar
The heterogeneity of protein AA in secondary (reactive)systemic amyloidosis.
February 1982, Biochimica et biophysica acta,
M Ravid, and Y Greenman, and J Shapira, and I Kedar
Is amyloid A (AA) amyloidosis always secondary?
April 1985, Annals of the rheumatic diseases,
M Ravid, and Y Greenman, and J Shapira, and I Kedar
Serum amyloid A (SAA)--the precursor of protein AA in secondary amyloidosis.
January 1988, Advances in experimental medicine and biology,
M Ravid, and Y Greenman, and J Shapira, and I Kedar
Human lysozyme inhibits the fibrillation of serum amyloid a protein from systemic AA amyloidosis.
December 2023, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis,
M Ravid, and Y Greenman, and J Shapira, and I Kedar
Serum amyloid A protein and C-reactive protein in systemic amyloidosis.
January 1985, Clinical and experimental rheumatology,
M Ravid, and Y Greenman, and J Shapira, and I Kedar
Serum amyloid A protein and C-reactive protein in systemic amyloidosis.
January 1986, Clinical and experimental rheumatology,
Copied contents to your clipboard!