Biomaterial Database

Calibration of a prompt neutron activation analysis facility for the measurement of total body protein. 1990

A Mackie, and S Cowen, and J Hannan

Department of Medical Physics and Medical Engineering, Western General Hospital, Edinburgh, UK.

Prompt neutron activation analysis with 252Cf has been used to measure total body protein. Since simultaneous irradiation and detection generated a high count rate at the detectors the nucleonic system was optimised to reduce distortions in the gamma ray energy spectrum. Tissue-equivalent phantoms were used to calibrate the apparatus. A total of 53 studies was performed on 39 normal subjects. Ratios of total body protein to fat-free mass agreed well with those from other centres and with cadaver studies. Duplicate measurements of 14 subjects gave a coefficient of variation of +/- 2.9% for a measurement of total body protein, which is close to that calculated from the known errors of the technique of +/- 2.7%. The whole body dose equivalent was 0.17 mSv.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009501	Neutron Activation Analysis	Activation analysis in which the specimen is bombarded with neutrons. Identification is made by measuring the resulting radioisotopes. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	Activation Analysis, Neutron,Analysis, Neutron Activation,Activation Analyses, Neutron,Analyses, Neutron Activation,Neutron Activation Analyses
D011506	Proteins	Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.	Gene Products, Protein,Gene Proteins,Protein,Protein Gene Products,Proteins, Gene
D012016	Reference Values	The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.	Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D001823	Body Composition	The relative amounts of various components in the body, such as percentage of body fat.	Body Compositions,Composition, Body,Compositions, Body
D002138	Calibration	Determination, by measurement or comparison with a standard, of the correct value of each scale reading on a meter or other measuring instrument; or determination of the settings of a control device that correspond to particular values of voltage, current, frequency or other output.	Calibrations
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000201	Activation Analysis	A method of chemical analysis based on the detection of characteristic radionuclides following a nuclear bombardment. It is also known as radioactivity analysis. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	Analysis, Activation,Activation Analyses,Analyses, Activation