The Hemopump is a new left-ventricular assist device (21 F diameter), which provides up to 3.5 L/min output after placement in the left ventricle via the femoral artery. We describe the first case in which the device was inserted during resuscitation. The patient developed untreatable sustained ventricular tachycardias/fibrillation 40 hours after coronary artery bypass grafting. After prolonged mechanical resuscitation (about 3 hours) as a last resort the Hemopump was inserted and rhythm and hemodynamics stabilized. In the following hours a decrease in aortic pressure pulsatility indicated, effective left ventricular support when the Hemopump was running. For short periods the patient had nonpulsatile aortic pressure wave forms, implying complete pump dependence. In this situation cardiac output was about 3.0 L/min, mean aortic pressure reached nearly 50 mmHg using high dosage of catecholamines. The patient remained pump-dependent and died due to untreatable ventricular fibrillation. There was no significant hemolysis during the 20 hours the Hemopump was running. Autopsy revealed no signs of thrombembolism, but intimal lesions of the A. iliaca and of the abdominal aorta with subsequent thrombus formation were demonstrated. In view of the experimentally proven benefit in cardiogenic shock and problems and risks caused by the insertion, future indications for clinical use of this new device are discussed.