-transparent.png){kind=logo}
Clostridium perfringens alpha toxin caused contraction of the isolated rat ileum in a dose-dependent manner. The contraction caused by the toxin was inhibited by verapamil, nifedipine, cinnarizine, but not by tetrodotoxin or incubation in a low Na+ medium. The toxin stimulated Ca2+ uptake in the ileum in a dose-dependent manner. Nifedipine completely inhibited the Ca2+ uptake into the ileum induced by the toxin. Furthermore, TMB-8, trifluoperazine, W-7 and H-7 significantly blocked the toxin-induced contraction. On the other hand, the toxin activated de novo production of phosphatidic acid and phosphatidylinositol in the tissue. These data suggest that the toxin-induced contraction is due to an increased Ca2+ permeability across the tissue, and activation of phospholipid metabolism.
J Sakurai, and
Y Fujii, and
M Shirotani
April 1989,
FEMS microbiology letters,
J Sakurai, and
Y Fujii, and
M Shirotani
April 1999,
Anaerobe,
J Sakurai, and
Y Fujii, and
M Shirotani
January 2002,
Acta microbiologica Polonica,
J Sakurai, and
Y Fujii, and
M Shirotani
January 2013,
Current pharmaceutical biotechnology,
J Sakurai, and
Y Fujii, and
M Shirotani
November 1945,
Journal of immunology (Baltimore, Md. : 1950),
J Sakurai, and
Y Fujii, and
M Shirotani
September 1994,
Nihon saikingaku zasshi. Japanese journal of bacteriology,
J Sakurai, and
Y Fujii, and
M Shirotani
January 1993,
Microbiology and immunology,
J Sakurai, and
Y Fujii, and
M Shirotani
December 1957,
A.M.A. archives of pathology,
J Sakurai, and
Y Fujii, and
M Shirotani
December 2008,
The Journal of pharmacology and experimental therapeutics,
J Sakurai, and
Y Fujii, and
M Shirotani
March 2017,
Chemistry and physics of lipids,
