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We have investigated the action of pimozide in tardive dyskinesia induced by prolonged administration of phenothiazines. Improvement was recorded in a double blind study of 18 patients treated with maximum tolerated dosage (mean 18.8 mg/day) for 6 weeks. There was no deterioration in the therapeutic action of pimozide over this time. Parkinsonism and sedation were the main adverse effects. They were corrected by reduction of the dose of pimozide, but often recurred so that further adjustments of dosage were necessary. Our findings support the view that tardive dyskinesia is produced by a disturbance in the balance of central transmitters such that dopaminergic transmission is increased.
L E Claveria, and
P F Teychenne, and
D B Calne, and
L Haskayne, and
A Petrie, and
C A Pallis, and
I C Lodge-Patch
January 1977,
Proceedings of the Royal Society of Medicine,
L E Claveria, and
P F Teychenne, and
D B Calne, and
L Haskayne, and
A Petrie, and
C A Pallis, and
I C Lodge-Patch
January 1980,
The Kurume medical journal,
L E Claveria, and
P F Teychenne, and
D B Calne, and
L Haskayne, and
A Petrie, and
C A Pallis, and
I C Lodge-Patch
October 1977,
Canadian Medical Association journal,
L E Claveria, and
P F Teychenne, and
D B Calne, and
L Haskayne, and
A Petrie, and
C A Pallis, and
I C Lodge-Patch
September 1990,
Journal of the National Medical Association,
L E Claveria, and
P F Teychenne, and
D B Calne, and
L Haskayne, and
A Petrie, and
C A Pallis, and
I C Lodge-Patch
July 1977,
Canadian Medical Association journal,
L E Claveria, and
P F Teychenne, and
D B Calne, and
L Haskayne, and
A Petrie, and
C A Pallis, and
I C Lodge-Patch
March 2024,
JAAD case reports,
L E Claveria, and
P F Teychenne, and
D B Calne, and
L Haskayne, and
A Petrie, and
C A Pallis, and
I C Lodge-Patch
November 2004,
Journal of psychiatry & neuroscience : JPN,
L E Claveria, and
P F Teychenne, and
D B Calne, and
L Haskayne, and
A Petrie, and
C A Pallis, and
I C Lodge-Patch
January 2009,
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry,
L E Claveria, and
P F Teychenne, and
D B Calne, and
L Haskayne, and
A Petrie, and
C A Pallis, and
I C Lodge-Patch
December 1979,
The British journal of psychiatry : the journal of mental science,
L E Claveria, and
P F Teychenne, and
D B Calne, and
L Haskayne, and
A Petrie, and
C A Pallis, and
I C Lodge-Patch
January 2020,
Tijdschrift voor psychiatrie,
