-transparent.png){kind=logo}
We investigated the effect of long-term i.v. administration of L-carnitine on human muscle fibers using morphometric parameters. We administered 2g/day L-carnitine to patients undergoing hemodialysis for at least 12 months. At the end of this period a marked increase in serum and muscle carnitine levels was observed in all patients, together with hypertrophy and predominance of type 1 fibers. L-carnitine was withheld for 4 months, during which time serum and muscle levels gradually decreased and no changes were observed in muscle fibers. Subsequent addition of L-carnitine to dialysis fluid for another 4 months stabilized lower levels. At the end of this period reduction of diameter of type 1 fibers was observed. Type 2 fibers remained unchanged. Moreover, type 1 fibers remained predominant in all cases. Hence, we suggest that carnitine has a specific trophic effect on type 1 fibers which are characterized by an oxidative metabolism.
L G Spagnoli, and
G Palmieri, and
A Mauriello, and
G M Vacha, and
S D'Iddio, and
G Giorcelli, and
M Corsi
December 1994,
Kidney international,
L G Spagnoli, and
G Palmieri, and
A Mauriello, and
G M Vacha, and
S D'Iddio, and
G Giorcelli, and
M Corsi
February 2006,
FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
L G Spagnoli, and
G Palmieri, and
A Mauriello, and
G M Vacha, and
S D'Iddio, and
G Giorcelli, and
M Corsi
June 1997,
Clinical nephrology,
L G Spagnoli, and
G Palmieri, and
A Mauriello, and
G M Vacha, and
S D'Iddio, and
G Giorcelli, and
M Corsi
February 1991,
The American journal of physiology,
L G Spagnoli, and
G Palmieri, and
A Mauriello, and
G M Vacha, and
S D'Iddio, and
G Giorcelli, and
M Corsi
April 2002,
Clinica chimica acta; international journal of clinical chemistry,
L G Spagnoli, and
G Palmieri, and
A Mauriello, and
G M Vacha, and
S D'Iddio, and
G Giorcelli, and
M Corsi
October 2006,
Bulletin of experimental biology and medicine,
L G Spagnoli, and
G Palmieri, and
A Mauriello, and
G M Vacha, and
S D'Iddio, and
G Giorcelli, and
M Corsi
August 1978,
Biochemical medicine,
L G Spagnoli, and
G Palmieri, and
A Mauriello, and
G M Vacha, and
S D'Iddio, and
G Giorcelli, and
M Corsi
September 2018,
Journal of basic and clinical physiology and pharmacology,
L G Spagnoli, and
G Palmieri, and
A Mauriello, and
G M Vacha, and
S D'Iddio, and
G Giorcelli, and
M Corsi
June 2017,
American journal of physiology. Cell physiology,
L G Spagnoli, and
G Palmieri, and
A Mauriello, and
G M Vacha, and
S D'Iddio, and
G Giorcelli, and
M Corsi
January 1989,
Pharmacological research,
