BACKGROUND Wound drains are often used after plastic and reconstructive surgery of the breast, in order to reduce potential complications. It is unclear whether there is any evidence to support this practice and we therefore undertook a systematic review of the best evidence available. OBJECTIVE To compare the safety and efficacy of the use of wound drains following elective plastic and reconstructive surgery procedures of the breast. METHODS We searched the Cochrane Wounds Group Specialised Register (searched 3 August 2012); The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 7); Ovid MEDLINE (1950 to July Week 4 2012); Ovid MEDLINE (In-Process & Other Non-Indexed Citations August 2, 2011); Ovid EMBASE (1980 to 2012 Week 30); and EBSCO CINAHL (1982 to 2 August 2012). There were no restrictions on the basis of date or language of publication. METHODS Two review authors undertook independent screening of the search results. All randomised trials that compared the use of a wound drain with no wound drain following plastic and reconstructive surgery of the breast (breast augmentation, breast reduction and breast reconstruction) in women were eligible. METHODS Two review authors undertook independent data extraction of study characteristics, methodological quality and outcomes (e.g. infection, other wound complications, pain, and length of hospital stay). Risk of bias was assessed independently by two review authors. We calculated the risk ratio (RR) for dichotomous outcomes and mean differences (MD) for continuous outcomes, with 95% confidence intervals. Analysis was on an intention-to-treat basis. RESULTS Three randomised trials were identified and included in the review out of 109 studies that were initially screened; all evaluated wound drainage after breast reduction surgery. In total there were 306 women in the three trials, and 505 breasts were studied (254 drained, and 251 who were not drained). Apart from a significantly shorter duration of hospital stay for those participants who did not have drains (MD 0.77; 95% CI 0.40 to 1.14), there was no statistically significant impact of the use of drains on outcomes. CONCLUSIONS The limited evidence available shows no significant benefit of using post-operative wound drains in reduction mammoplasty, though hospital stay may be shorter when drains are not used. No data are available for breast augmentation or breast reconstruction, and this requires investigation.