-transparent.png){kind=logo}
This experiment examined the effects of intracerebroventricular (i.c.v.) administration of a corticotropin-releasing factor (CRF) antagonist on the development of stress-induced sensitization of the behavioral response to amphetamine. Restraint stress was found to enhance both the locomotor response to a s.c. injection of saline and the intensity of stereotypy induced by a s.c. injection of 3.0 mg/kg D-amphetamine. Both of these effects of restraint stress were severely attenuated in rats that had been injected with the CRF antagonist prior to restraint stress. This result is compatible with the hypothesis that CRF is critically involved in initiating behavioral and physiological responses to aversive stimuli.
B J Cole, and
M Cador, and
L Stinus, and
J Rivier, and
W Vale, and
G F Koob, and
M Le Moal
March 2000,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
B J Cole, and
M Cador, and
L Stinus, and
J Rivier, and
W Vale, and
G F Koob, and
M Le Moal
March 1999,
Synapse (New York, N.Y.),
B J Cole, and
M Cador, and
L Stinus, and
J Rivier, and
W Vale, and
G F Koob, and
M Le Moal
January 1988,
Peptides,
B J Cole, and
M Cador, and
L Stinus, and
J Rivier, and
W Vale, and
G F Koob, and
M Le Moal
February 1997,
The Journal of pharmacology and experimental therapeutics,
B J Cole, and
M Cador, and
L Stinus, and
J Rivier, and
W Vale, and
G F Koob, and
M Le Moal
December 1995,
Annals of the New York Academy of Sciences,
B J Cole, and
M Cador, and
L Stinus, and
J Rivier, and
W Vale, and
G F Koob, and
M Le Moal
September 1986,
Brain research bulletin,
B J Cole, and
M Cador, and
L Stinus, and
J Rivier, and
W Vale, and
G F Koob, and
M Le Moal
February 2010,
European journal of pharmacology,
B J Cole, and
M Cador, and
L Stinus, and
J Rivier, and
W Vale, and
G F Koob, and
M Le Moal
November 2008,
Neuroscience,
B J Cole, and
M Cador, and
L Stinus, and
J Rivier, and
W Vale, and
G F Koob, and
M Le Moal
March 2000,
Alcoholism, clinical and experimental research,
B J Cole, and
M Cador, and
L Stinus, and
J Rivier, and
W Vale, and
G F Koob, and
M Le Moal
August 2011,
Neuroscience,
