Biomaterial Database

Zinc, copper and manganese in serum, urine and stones. 1990

K Komleh, and P Hada, and A K Pendse, and P P Singh

Department of Biochemistry, R.N.T. Medical College, Udaipur, India.

Serum zinc, copper and manganese levels were estimated in normal subjects (NS) and stone formers (SF). There was no significant difference in the serum levels of Zn, Cu, and Mn in NS and SF, the values being 101.5 +/- 35.1 micrograms% and 94.3 +/- 45.6 for Zn; 91.75 +/- 27.0 micrograms% and 88.5 +/- 34.1 for Cu; and 87.0 +/- 36.7 micrograms% and 79.6 +/- 35.5 for Mn, respectively. Zinc excretion was relatively high in NS (790.08 +/- 172.88 micrograms/dl) as compared to other populations and was significantly higher in SF (1154.92 +/- 290.17 micrograms%, p less than 0.001). Copper and manganese excretions in SF were significantly lower than in NS (p less than 0.001). Zinc was present in substantial quantities in renal (2.52 +/- 3.98 g%), ureteric (0.75 +/- 0.51 g%) and vesical (1.71 +/- 3.20 g%) stones. Manganese was present in traces in all the stones and copper in two-thirds of the stones.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008345	Manganese	A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
D003300	Copper	A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.	Copper-63,Copper 63
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014545	Urinary Calculi	Low-density crystals or stones in any part of the URINARY TRACT. Their chemical compositions often include CALCIUM OXALATE, magnesium ammonium phosphate (struvite), CYSTINE, or URIC ACID.	Urinary Stones,Urinary Tract Stones,Calculi, Urinary,Calculus, Urinary,Stone, Urinary,Stone, Urinary Tract,Stones, Urinary,Stones, Urinary Tract,Urinary Calculus,Urinary Stone,Urinary Tract Stone
D015032	Zinc	A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.