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The rapidly sedimenting hemagglutinin (RHA) representing the purified virion and the slower-sedimenting hemagglutinin (SHA) of several flaviviruses were separated and used in hemagglutination inhibition tests with the 19S (immunoglobulin M) and 7S (immunoglobulin G) immunoglobulin fractions of rabbit antisera, prepared against purified viral antigens or against crude virus pools. The antibody specificity in tests with RHA was identical to the specificity in those employing SHA. 7S antibody cross-reacted broadly with all flavivirus antigens, whereas 19S antibodies were relatively specific in cross-reactions among flaviviruses (RHA or SHA). SHA was consistently inhibited by antibody to a greater extent than RHA. Anti-envelope protein, anti-RHA antibodies and anti-SHA antibodies were unable to discriminate between RHA and SHA. It was concluded that the relative amounts of RHA or SHA in crude hemagglutinin preparations have no influence on the result of hemagglutination inhibition tests with flaviviruses.
E G Westaway, and
M Shew, and
A J Della-Porta
August 1967,
Science (New York, N.Y.),
E G Westaway, and
M Shew, and
A J Della-Porta
January 1975,
Problemy tuberkuleza,
E G Westaway, and
M Shew, and
A J Della-Porta
February 1967,
Immunology,
E G Westaway, and
M Shew, and
A J Della-Porta
March 1964,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
E G Westaway, and
M Shew, and
A J Della-Porta
March 1967,
Immunology,
E G Westaway, and
M Shew, and
A J Della-Porta
December 1970,
Clinical and experimental immunology,
E G Westaway, and
M Shew, and
A J Della-Porta
October 1969,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
E G Westaway, and
M Shew, and
A J Della-Porta
November 1968,
Journal of immunology (Baltimore, Md. : 1950),
E G Westaway, and
M Shew, and
A J Della-Porta
January 1969,
Pediatriia,
E G Westaway, and
M Shew, and
A J Della-Porta
November 1967,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
