Exophthalmos: A Forgotten Clinical Sign of Cushing's Syndrome. 2013

Aldo Schenone Giugni, and Shylaja Mani, and Subramanian Kannan, and Betul Hatipoglu
Department of Internal Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue Desk NA10, Cleveland, OH 44195, USA.

Exophthalmos is typically associated with Graves' ophthalmopathy. Although originally described by Harvey Cushing, exophthalmos is an underappreciated sign of Cushing's syndrome. We present a case of a 38-year-old female who presented with severe bilateral proptosis and was subsequently diagnosed with Cushings disease. We discuss the possible mechanisms causing exophthalmos in patients with either endogenous or exogenous hypercortisolemia.

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