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ICLAS Working Group on Harmonization: international guidance concerning the production care and use of genetically-altered animals. 2013

M Rose, and J Everitt, and H Hedrich, and J Schofield, and M Dennis, and E Scott, and G Griffin, and
Prince of Wales Clinical School, University of New South Wales, Australia.

Replacement, Reduction and Refinement, the ‘Three Rs’ of Russell & Burch, are accepted worldwide as fundamental to the ethics of animal experimentation. The production, care and use of genetically-altered animals can pose particular challenges to the implementation of the Three Rs,1 necessitating additional considerations by those responsible for overseeing the ethical use and appropriate care of animals involved in science. The International Council for Laboratory Animal Science brings representatives of the international laboratory animal science community together to recommend acceptance of guidance documents.The harmonization of guidance concerning genetically-altered animals was seen as a priority because of the increasing globalization of research involving these animals.

UI MeSH Term Description Entries
D007756 Laboratory Animal Science The science and technology dealing with the procurement, breeding, care, health, and selection of animals used in biomedical research and testing. Animal Science, Laboratory,Animal Sciences, Laboratory,Laboratory Animal Sciences,Science, Laboratory Animal,Sciences, Laboratory Animal
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000827 Animal Welfare The protection of animals in laboratories or other specific environments by promoting their health through better nutrition, housing, and care. Animal Cruelty,Cruelty, Animal,Welfare, Animal
D030801 Animals, Genetically Modified ANIMALS whose GENOME has been altered by GENETIC ENGINEERING, or their offspring. Animals, Transgenic,Genetically Modified Animals,Transgenic Animals,Founder Animals, Transgenic,GMO Animals,Genetically Engineered Animals,Animal, GMO,Animal, Genetically Engineered,Animal, Genetically Modified,Animal, Transgenic,Animal, Transgenic Founder,Animals, GMO,Animals, Genetically Engineered,Animals, Transgenic Founder,Engineered Animal, Genetically,Engineered Animals, Genetically,Founder Animal, Transgenic,GMO Animal,Genetically Engineered Animal,Genetically Modified Animal,Modified Animal, Genetically,Modified Animals, Genetically,Transgenic Animal,Transgenic Founder Animal,Transgenic Founder Animals
D032761 Animal Experimentation The use of animals as investigational subjects. Animal Experimental Use,Animal Experiments,Animal Research,Animal Experiment,Animal Experimental Uses,Experiment, Animal,Experimental Use, Animal,Experimental Uses, Animal,Experimentation, Animal,Experiments, Animal,Research, Animal

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