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Reliable techniques for the calculation of activity product (state of saturation), formation product (limit of metastability) and crystal growth of calcium oxalate were devised. The activity product at saturation was 2.53 times 10 minus 9 M2, and was independent of duration of incubation, solid-to-solution ratio, pH, calcium concentration or ionic strength. These tehcniques were utilized to assess the effect of disodium ethane-1-hydroxy-1, 1-diphosphonate (EHDP) on crystallization of calcium oxalate in an aqueous salt solution in vitro. EHDP increased the formation product of calcium oxalate, indicating an inhibition of nucleation of calcium oxalate. Further, it inhibited the crystal growth of calcium oxalate.
C Y Pak, and
M Ohata, and
K Holt
December 1973,
Kidney international,
C Y Pak, and
M Ohata, and
K Holt
January 2008,
International urology and nephrology,
C Y Pak, and
M Ohata, and
K Holt
January 1984,
Nephrologie,
C Y Pak, and
M Ohata, and
K Holt
February 1990,
Calcified tissue international,
C Y Pak, and
M Ohata, and
K Holt
January 2012,
Annales de biologie clinique,
C Y Pak, and
M Ohata, and
K Holt
August 1999,
Urological research,
C Y Pak, and
M Ohata, and
K Holt
October 2011,
Natural product communications,
C Y Pak, and
M Ohata, and
K Holt
May 2010,
Indian journal of pharmaceutical sciences,
C Y Pak, and
M Ohata, and
K Holt
September 1988,
Kidney international,
C Y Pak, and
M Ohata, and
K Holt
June 1999,
BJU international,
