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Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV. 2013
Mark J Mitton-Fry, and
Steven J Brickner, and
Judith C Hamel, and
Lori Brennan, and
Jeffrey M Casavant, and
Michael Chen, and
Tao Chen, and
Xiaoyuan Ding, and
James Driscoll, and
Joel Hardink, and
Thuy Hoang, and
Erbing Hua, and
Michael D Huband, and
Meghan Maloney, and
Anthony Marfat, and
Sandra P McCurdy, and
Dale McLeod, and
Michael Plotkin, and
Usa Reilly, and
Shaughn Robinson, and
John Schafer, and
Richard M Shepard, and
James F Smith, and
Gregory G Stone, and
Chakrapani Subramanyam, and
Kwansik Yoon, and
Wei Yuan, and
Richard P Zaniewski, and
Christopher Zook
Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA. mjmitton@owu.edu
A structurally novel set of inhibitors of bacterial type II topoisomerases with potent in vitro and in vivo antibacterial activity was developed. Dual-targeting ability, hERG inhibition, and pharmacokinetic properties were also assessed.
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Judith C Hamel, and
Lori Brennan, and
Jeffrey M Casavant, and
Michael Chen, and
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Meghan Maloney, and
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Tao Chen, and
Xiaoyuan Ding, and
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Joel Hardink, and
Thuy Hoang, and
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Jeffrey M Casavant, and
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Tao Chen, and
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John Schafer, and
Richard M Shepard, and
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Wei Yuan, and
Richard P Zaniewski, and
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James Driscoll, and
Joel Hardink, and
Thuy Hoang, and
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James Driscoll, and
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Meghan Maloney, and
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Thuy Hoang, and
Erbing Hua, and
Michael D Huband, and
Meghan Maloney, and
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Judith C Hamel, and
Lori Brennan, and
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Tao Chen, and
Xiaoyuan Ding, and
James Driscoll, and
Joel Hardink, and
Thuy Hoang, and
Erbing Hua, and
Michael D Huband, and
Meghan Maloney, and
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Dale McLeod, and
Michael Plotkin, and
Usa Reilly, and
Shaughn Robinson, and
John Schafer, and
Richard M Shepard, and
James F Smith, and
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Chakrapani Subramanyam, and
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Wei Yuan, and
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Xiaoyuan Ding, and
James Driscoll, and
Joel Hardink, and
Thuy Hoang, and
Erbing Hua, and
Michael D Huband, and
Meghan Maloney, and
Anthony Marfat, and
Sandra P McCurdy, and
Dale McLeod, and
Michael Plotkin, and
Usa Reilly, and
Shaughn Robinson, and
John Schafer, and
Richard M Shepard, and
James F Smith, and
Gregory G Stone, and
Chakrapani Subramanyam, and
Kwansik Yoon, and
Wei Yuan, and
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