BIOMAT Database Logo BIOMAT Database Logo

(S)-4-(3-18F-fluoropropyl)-L-glutamic acid: an 18F-labeled tumor-specific probe for PET/CT imaging--dosimetry. 2013

Kamilla Smolarz, and Bernd Joachim Krause, and Frank-Philipp Graner, and Franziska Martina Wagner, and Christina Hultsch, and Claudia Bacher-Stier, and Richard B Sparks, and Susan Ramsay, and Lüder M Fels, and Ludger M Dinkelborg, and Markus Schwaiger
Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, München, Germany. kamilla.smolarz@tum.de

The glutamic acid derivative (S)-4-(3-(18)F-Fluoropropyl)-l-glutamic acid ((18)F-FSPG, alias BAY 94-9392), a new PET tracer for the detection of malignant diseases, displayed promising results in non-small cell lung cancer patients. The aim of this study was to provide dosimetry estimates for (18)F-FSPG based on human whole-body PET/CT measurements. METHODS (18)F-FSPG was prepared by a fully automated 2-step procedure and purified by a solid-phase extraction method. PET/CT scans were obtained for 5 healthy volunteers (mean age, 59 y; age range, 51-64 y; 2 men, 3 women). Human subjects were imaged for up to 240 min using a PET/CT scanner after intravenous injection of 299 ± 22.5 MBq of (18)F-FSPG. Image quantification, time-activity data modeling, estimation of normalized number of disintegrations, and production of dosimetry estimates were performed using the RADAR (RAdiation Dose Assessment Resource) method for internal dosimetry and in general concordance with the methodology and principles as presented in the MIRD 16 document. RESULTS Because of the renal excretion of the tracer, the absorbed dose was highest in the urinary bladder wall and kidneys, followed by the pancreas and uterus. The individual organ doses (mSv/MBq) were 0.40 ± 0.058 for the urinary bladder wall, 0.11 ± 0.011 for the kidneys, 0.077 ± 0.020 for the pancreas, and 0.030 ± 0.0034 for the uterus. The calculated effective dose was 0.032 ± 0.0034 mSv/MBq. Absorbed dose to the bladder and the effective dose can be reduced significantly by frequent bladder-voiding intervals. For a 0.75-h voiding interval, the bladder dose was reduced to 0.10 ± 0.012 mSv/MBq, and the effective dose was reduced to 0.015 ± 0.0010 mSv/MBq. CONCLUSIONS On the basis of the distribution and biokinetic data, the determined radiation dose for (18)F-FSPG was calculated to be 9.5 ± 1.0 mSv at a patient dose of 300 MBq, which is of similar magnitude to that of (18)F-FDG (5.7 mSv). The effective dose can be reduced to 4.5 ± 0.30 mSv (at 300 MBq), with a bladder-voiding interval of 0.75 h.

UI MeSH Term Description Entries
D007553 Isotope Labeling Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms. Isotope Labeling, Stable,Isotope-Coded Affinity Tagging,Isotopically-Coded Affinity Tagging,Affinity Tagging, Isotope-Coded,Affinity Tagging, Isotopically-Coded,Isotope Coded Affinity Tagging,Labeling, Isotope,Labeling, Stable Isotope,Stable Isotope Labeling,Tagging, Isotope-Coded Affinity,Tagging, Isotopically-Coded Affinity
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009369 Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D011874 Radiometry The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by SCINTILLATION COUNTING. Geiger-Mueller Counters,Nuclear Track Detection,Radiation Dosimetry,Dosimetry, Radiation,Geiger Counter,Geiger-Mueller Counter Tube,Geiger-Mueller Probe,Geiger-Mueller Tube,Radiation Counter,Counter Tube, Geiger-Mueller,Counter Tubes, Geiger-Mueller,Counter, Geiger,Counter, Radiation,Counters, Geiger,Counters, Geiger-Mueller,Counters, Radiation,Detection, Nuclear Track,Dosimetries, Radiation,Geiger Counters,Geiger Mueller Counter Tube,Geiger Mueller Counters,Geiger Mueller Probe,Geiger Mueller Tube,Geiger-Mueller Counter Tubes,Geiger-Mueller Probes,Geiger-Mueller Tubes,Probe, Geiger-Mueller,Probes, Geiger-Mueller,Radiation Counters,Radiation Dosimetries,Tube, Geiger-Mueller,Tube, Geiger-Mueller Counter,Tubes, Geiger-Mueller,Tubes, Geiger-Mueller Counter
D005260 Female Females
D005971 Glutamates Derivatives of GLUTAMIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-aminopentanedioic acid structure. Glutamic Acid Derivatives,Glutamic Acids,Glutaminic Acids
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012449 Safety Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property. Safeties
D014057 Tomography, X-Ray Computed Tomography using x-ray transmission and a computer algorithm to reconstruct the image. CAT Scan, X-Ray,CT Scan, X-Ray,Cine-CT,Computerized Tomography, X-Ray,Electron Beam Computed Tomography,Tomodensitometry,Tomography, Transmission Computed,X-Ray Tomography, Computed,CAT Scan, X Ray,CT X Ray,Computed Tomography, X-Ray,Computed X Ray Tomography,Computerized Tomography, X Ray,Electron Beam Tomography,Tomography, X Ray Computed,Tomography, X-Ray Computer Assisted,Tomography, X-Ray Computerized,Tomography, X-Ray Computerized Axial,Tomography, Xray Computed,X Ray Computerized Tomography,X Ray Tomography, Computed,X-Ray Computer Assisted Tomography,X-Ray Computerized Axial Tomography,Beam Tomography, Electron,CAT Scans, X-Ray,CT Scan, X Ray,CT Scans, X-Ray,CT X Rays,Cine CT,Computed Tomography, Transmission,Computed Tomography, X Ray,Computed Tomography, Xray,Computed X-Ray Tomography,Scan, X-Ray CAT,Scan, X-Ray CT,Scans, X-Ray CAT,Scans, X-Ray CT,Tomographies, Computed X-Ray,Tomography, Computed X-Ray,Tomography, Electron Beam,Tomography, X Ray Computer Assisted,Tomography, X Ray Computerized,Tomography, X Ray Computerized Axial,Transmission Computed Tomography,X Ray Computer Assisted Tomography,X Ray Computerized Axial Tomography,X Ray, CT,X Rays, CT,X-Ray CAT Scan,X-Ray CAT Scans,X-Ray CT Scan,X-Ray CT Scans,X-Ray Computed Tomography,X-Ray Computerized Tomography,Xray Computed Tomography

Related Publications

Kamilla Smolarz, and Bernd Joachim Krause, and Frank-Philipp Graner, and Franziska Martina Wagner, and Christina Hultsch, and Claudia Bacher-Stier, and Richard B Sparks, and Susan Ramsay, and Lüder M Fels, and Ludger M Dinkelborg, and Markus Schwaiger
Assessment of Tumor Redox Status through (S)-4-(3-[18F]fluoropropyl)-L-Glutamic Acid PET Imaging of System xc - Activity.
February 2019, Cancer research,
Kamilla Smolarz, and Bernd Joachim Krause, and Frank-Philipp Graner, and Franziska Martina Wagner, and Christina Hultsch, and Claudia Bacher-Stier, and Richard B Sparks, and Susan Ramsay, and Lüder M Fels, and Ludger M Dinkelborg, and Markus Schwaiger
Radiosynthesis and Analysis of (S)-4-(3-[18F]Fluoropropyl)-L-Glutamic Acid.
June 2023, Molecular imaging and biology,
Kamilla Smolarz, and Bernd Joachim Krause, and Frank-Philipp Graner, and Franziska Martina Wagner, and Christina Hultsch, and Claudia Bacher-Stier, and Richard B Sparks, and Susan Ramsay, and Lüder M Fels, and Ludger M Dinkelborg, and Markus Schwaiger
Synthesis and analysis of 4-(3-fluoropropyl)-glutamic acid stereoisomers to determine the stereochemical purity of (4S)-4-(3-[18F]fluoropropyl)-L-glutamic acid ([18F]FSPG) for clinical use.
January 2020, PloS one,
Kamilla Smolarz, and Bernd Joachim Krause, and Frank-Philipp Graner, and Franziska Martina Wagner, and Christina Hultsch, and Claudia Bacher-Stier, and Richard B Sparks, and Susan Ramsay, and Lüder M Fels, and Ludger M Dinkelborg, and Markus Schwaiger
Pilot Preclinical and Clinical Evaluation of (4S)-4-(3-[18F]Fluoropropyl)-L-Glutamate (18F-FSPG) for PET/CT Imaging of Intracranial Malignancies.
January 2016, PloS one,
Kamilla Smolarz, and Bernd Joachim Krause, and Frank-Philipp Graner, and Franziska Martina Wagner, and Christina Hultsch, and Claudia Bacher-Stier, and Richard B Sparks, and Susan Ramsay, and Lüder M Fels, and Ludger M Dinkelborg, and Markus Schwaiger
Clinical Evaluation of (4S)-4-(3-[18F]Fluoropropyl)-L-glutamate (18F-FSPG) for PET/CT Imaging in Patients with Newly Diagnosed and Recurrent Prostate Cancer.
October 2020, Clinical cancer research : an official journal of the American Association for Cancer Research,
Kamilla Smolarz, and Bernd Joachim Krause, and Frank-Philipp Graner, and Franziska Martina Wagner, and Christina Hultsch, and Claudia Bacher-Stier, and Richard B Sparks, and Susan Ramsay, and Lüder M Fels, and Ludger M Dinkelborg, and Markus Schwaiger
Radiosynthesis and biological evaluation of L- and D-S-(3-[18F]fluoropropyl)homocysteine for tumor imaging using positron emission tomography.
March 2011, Journal of medicinal chemistry,
Kamilla Smolarz, and Bernd Joachim Krause, and Frank-Philipp Graner, and Franziska Martina Wagner, and Christina Hultsch, and Claudia Bacher-Stier, and Richard B Sparks, and Susan Ramsay, and Lüder M Fels, and Ludger M Dinkelborg, and Markus Schwaiger
18F labeled nanoparticles for in vivo PET-CT imaging.
February 2009, Bioconjugate chemistry,
Kamilla Smolarz, and Bernd Joachim Krause, and Frank-Philipp Graner, and Franziska Martina Wagner, and Christina Hultsch, and Claudia Bacher-Stier, and Richard B Sparks, and Susan Ramsay, and Lüder M Fels, and Ludger M Dinkelborg, and Markus Schwaiger
Radiation dosimetry of O-(3-[18F]fluoropropyl)-L-tyrosine as oncologic PET tracer based on the mice distribution data.
January 2004, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
Kamilla Smolarz, and Bernd Joachim Krause, and Frank-Philipp Graner, and Franziska Martina Wagner, and Christina Hultsch, and Claudia Bacher-Stier, and Richard B Sparks, and Susan Ramsay, and Lüder M Fels, and Ludger M Dinkelborg, and Markus Schwaiger
Synthesis and evaluation of O-(3-[18F]fluoropropyl)-L-tyrosine as an oncologic PET tracer.
October 2003, Nuclear medicine and biology,
Kamilla Smolarz, and Bernd Joachim Krause, and Frank-Philipp Graner, and Franziska Martina Wagner, and Christina Hultsch, and Claudia Bacher-Stier, and Richard B Sparks, and Susan Ramsay, and Lüder M Fels, and Ludger M Dinkelborg, and Markus Schwaiger
Imaging prostate derived tumors with PET and N-(3-[18F]fluoropropyl)putrescine.
January 1990, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology,
Copied contents to your clipboard!