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Previous research has revealed that Wnt10b activates canonical Wnt signaling, which is integral to melanocyte differentiation in hair follicles (HFs). However, the function of Wnt10b in HF melanocytes remains poorly understood. We determined using Dct-LacZ transgenic mice that Wnt10b is mainly expressed near and within melanocytes of the hair bulbs during the anagen stage of the hair cycle. We also found that Wnt10b promotes an increase in melanocyte maturation and pigmentation in the hair bulbs of the mouse HF. To further explore the potential functions of Wnt10b in mouse HF melanocytes, we infected iMC23 cells with Ad-Wnt10b to overexpress Wnt10b. We demonstrated that Wnt10b promotes the differentiation of melanocytes by activating canonical Wnt signaling in melanocytes.
Jixing Ye, and
Tian Yang, and
Haiying Guo, and
Yinhong Tang, and
Fang Deng, and
Yuhong Li, and
Yizhan Xing, and
Li Yang, and
Ke Yang
June 2014,
Experimental dermatology,
Jixing Ye, and
Tian Yang, and
Haiying Guo, and
Yinhong Tang, and
Fang Deng, and
Yuhong Li, and
Yizhan Xing, and
Li Yang, and
Ke Yang
April 2024,
Genomics,
Jixing Ye, and
Tian Yang, and
Haiying Guo, and
Yinhong Tang, and
Fang Deng, and
Yuhong Li, and
Yizhan Xing, and
Li Yang, and
Ke Yang
October 2020,
Annals of dermatology,
Jixing Ye, and
Tian Yang, and
Haiying Guo, and
Yinhong Tang, and
Fang Deng, and
Yuhong Li, and
Yizhan Xing, and
Li Yang, and
Ke Yang
April 2007,
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
Jixing Ye, and
Tian Yang, and
Haiying Guo, and
Yinhong Tang, and
Fang Deng, and
Yuhong Li, and
Yizhan Xing, and
Li Yang, and
Ke Yang
December 2020,
Annals of dermatology,
Jixing Ye, and
Tian Yang, and
Haiying Guo, and
Yinhong Tang, and
Fang Deng, and
Yuhong Li, and
Yizhan Xing, and
Li Yang, and
Ke Yang
January 2017,
Stem cells international,
Jixing Ye, and
Tian Yang, and
Haiying Guo, and
Yinhong Tang, and
Fang Deng, and
Yuhong Li, and
Yizhan Xing, and
Li Yang, and
Ke Yang
April 1975,
The Journal of investigative dermatology,
Jixing Ye, and
Tian Yang, and
Haiying Guo, and
Yinhong Tang, and
Fang Deng, and
Yuhong Li, and
Yizhan Xing, and
Li Yang, and
Ke Yang
January 2020,
Methods in molecular biology (Clifton, N.J.),
Jixing Ye, and
Tian Yang, and
Haiying Guo, and
Yinhong Tang, and
Fang Deng, and
Yuhong Li, and
Yizhan Xing, and
Li Yang, and
Ke Yang
April 2023,
Dermatology practical & conceptual,
Jixing Ye, and
Tian Yang, and
Haiying Guo, and
Yinhong Tang, and
Fang Deng, and
Yuhong Li, and
Yizhan Xing, and
Li Yang, and
Ke Yang
January 2016,
International journal of medical sciences,
