-transparent.png){kind=logo}
Concomitant daily treatment of newborn rats for a 2-week to 1-month period with 10 mug/g of body weight of nerve growth factor and 100 mug/g of body weight of 6-hydroxydopamine produces in the cell bodies of adrenergic neurons the characteristic effects of the growth factor but in the nerve terminals the characteristic effects of 6-hydroxydopamine. The dual opposite effects result in a striking volume increase of sympathetic ganglia which far exceeds that produced by nerve growth factor alone. The selective induction of tyrosine hydroxylase [L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] in these chemically axotomized adrenergic neurons is even more pronounced than that produced by nerve growth factor alone in intact neurons.
R Levi-Montalcini, and
L Aloe, and
E Mugnaini, and
F Oesch, and
H Thoenen
September 1977,
Brain research,
R Levi-Montalcini, and
L Aloe, and
E Mugnaini, and
F Oesch, and
H Thoenen
July 1974,
Nature,
R Levi-Montalcini, and
L Aloe, and
E Mugnaini, and
F Oesch, and
H Thoenen
March 1975,
Brain research,
R Levi-Montalcini, and
L Aloe, and
E Mugnaini, and
F Oesch, and
H Thoenen
July 1977,
Proceedings of the National Academy of Sciences of the United States of America,
R Levi-Montalcini, and
L Aloe, and
E Mugnaini, and
F Oesch, and
H Thoenen
December 1977,
Proceedings of the National Academy of Sciences of the United States of America,
R Levi-Montalcini, and
L Aloe, and
E Mugnaini, and
F Oesch, and
H Thoenen
July 1971,
Proceedings of the National Academy of Sciences of the United States of America,
R Levi-Montalcini, and
L Aloe, and
E Mugnaini, and
F Oesch, and
H Thoenen
November 1978,
The Journal of biological chemistry,
R Levi-Montalcini, and
L Aloe, and
E Mugnaini, and
F Oesch, and
H Thoenen
September 1972,
Brain research,
R Levi-Montalcini, and
L Aloe, and
E Mugnaini, and
F Oesch, and
H Thoenen
January 1973,
Naunyn-Schmiedeberg's archives of pharmacology,
R Levi-Montalcini, and
L Aloe, and
E Mugnaini, and
F Oesch, and
H Thoenen
April 1977,
Journal of neurochemistry,
