[Correlation between in vitro release and in vivo absorption of sustained-releasing tablets of neostigmine bromide]. 2013

Wen Luo, and Qun-You Tan, and Hua-Rong Xiong, and Chun-Jing Zhao, and Jing-Qing Zhang
Medicine Engineering Research Center, Chongqing Key Laboratory of Biochemical&Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, China.

OBJECTIVE To determine the correlation between in vitro release and in vivo absorption of sustained-releasing tablets of neostigmine bromide. METHODS Water was used as dissolution medium to measured in vitro release of neostigmine bromide. After a single oral administration of 100 mg neostigmine bromide to rabbits, the plasma concentrations of neostigmine bromide in the rabbits were determined by HPLC. The compartment model and deconvolution method were employed to explain the in vitro-in vivo correlation. RESULTS Using Y as cumulative in vitro release and Fa as percentage of absorption, the regression equation was established: Fa = 0.9298Y + 4.6074, r = 0.9961. The input function of R = 2.0163Y-11.242,r = 0.9270. CONCLUSIONS The correlation between in vitro release and in vivo absorption of neostigmine bromide is good.

UI MeSH Term Description Entries
D009388 Neostigmine A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier. Synstigmin,Neostigmine Bromide,Neostigmine Methylsulfate,Polstigmine,Proserine,Prostigmin,Prostigmine,Prozerin,Syntostigmine,Bromide, Neostigmine,Methylsulfate, Neostigmine
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D002851 Chromatography, High Pressure Liquid Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed. Chromatography, High Performance Liquid,Chromatography, High Speed Liquid,Chromatography, Liquid, High Pressure,HPLC,High Performance Liquid Chromatography,High-Performance Liquid Chromatography,UPLC,Ultra Performance Liquid Chromatography,Chromatography, High-Performance Liquid,High-Performance Liquid Chromatographies,Liquid Chromatography, High-Performance
D003692 Delayed-Action Preparations Dosage forms of a drug that act over a period of time by controlled-release processes or technology. Controlled Release Formulation,Controlled-Release Formulation,Controlled-Release Preparation,Delayed-Action Preparation,Depot Preparation,Depot Preparations,Extended Release Formulation,Extended Release Preparation,Prolonged-Action Preparation,Prolonged-Action Preparations,Sustained Release Formulation,Sustained-Release Preparation,Sustained-Release Preparations,Timed-Release Preparation,Timed-Release Preparations,Controlled-Release Formulations,Controlled-Release Preparations,Extended Release Formulations,Extended Release Preparations,Slow Release Formulation,Sustained Release Formulations,Controlled Release Formulations,Controlled Release Preparation,Controlled Release Preparations,Delayed Action Preparation,Delayed Action Preparations,Formulation, Controlled Release,Formulations, Controlled Release,Prolonged Action Preparation,Release Formulation, Controlled,Release Formulations, Controlled,Sustained Release Preparation,Timed Release Preparation,Timed Release Preparations
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012995 Solubility The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Solubilities
D013607 Tablets Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed) Tablet

Related Publications

Wen Luo, and Qun-You Tan, and Hua-Rong Xiong, and Chun-Jing Zhao, and Jing-Qing Zhang
October 2013, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Wen Luo, and Qun-You Tan, and Hua-Rong Xiong, and Chun-Jing Zhao, and Jing-Qing Zhang
April 2022, Molecules (Basel, Switzerland),
Wen Luo, and Qun-You Tan, and Hua-Rong Xiong, and Chun-Jing Zhao, and Jing-Qing Zhang
February 2006, Drug development and industrial pharmacy,
Wen Luo, and Qun-You Tan, and Hua-Rong Xiong, and Chun-Jing Zhao, and Jing-Qing Zhang
November 1990, Pharmaceutical research,
Wen Luo, and Qun-You Tan, and Hua-Rong Xiong, and Chun-Jing Zhao, and Jing-Qing Zhang
July 1983, International journal of clinical pharmacology, therapy, and toxicology,
Wen Luo, and Qun-You Tan, and Hua-Rong Xiong, and Chun-Jing Zhao, and Jing-Qing Zhang
March 1971, Acta pharmaceutica Suecica,
Wen Luo, and Qun-You Tan, and Hua-Rong Xiong, and Chun-Jing Zhao, and Jing-Qing Zhang
March 2011, AAPS PharmSciTech,
Wen Luo, and Qun-You Tan, and Hua-Rong Xiong, and Chun-Jing Zhao, and Jing-Qing Zhang
April 2008, Pakistan journal of pharmaceutical sciences,
Wen Luo, and Qun-You Tan, and Hua-Rong Xiong, and Chun-Jing Zhao, and Jing-Qing Zhang
August 2007, International journal of pharmaceutics,
Wen Luo, and Qun-You Tan, and Hua-Rong Xiong, and Chun-Jing Zhao, and Jing-Qing Zhang
November 1968, Acta pharmaceutica Suecica,
Copied contents to your clipboard!