Epithelial-mesenchymal transition triggers cancer stem cell generation in human thyroid cancer cells. 2013

Ling Lan, and Yong Luo, and Dai Cui, and Bing-Yin Shi, and Wei Deng, and Li-Li Huo, and Hai-Ling Chen, and Guo-Ying Zhang, and Li-Li Deng
Department of Endocrinology, Beijing Ji Shui Tan Hospital, The 4th Medical College of Peking University, Beijing, P.R. China. lanjingling0627@hotmail.com

Increasing evidence has shown that cancer stem cells or tumor initiating cells are the 'root cause' of malignant cancers. However, the exact origin of cancer stem cells still remains obscure in thyroid research. EMT has been implicated in the initiation and conversion of early-stage tumors into invasive malignancies and is associated with the stemness of cancer cells. Based on these facts, a new hypothesis was suggested that EMT induces cancer stem cell generation and tumor progression in human thyroid cancer cells in vitro. In the present study, FTC133 cells identified as EMT-negative cells were used for EMT induction by HIF‑1α transfection. Overexpression of HIF-1α induced FTC133 cells to undergo EMT, downregulated the epithelial markers E-cadherin, upregulated the mesenchymal marker vimentin, and associated with highly invasive and metastatic properties. Most importantly, the induction of EMT promoted the stem-like side population cell proportion in the FTC133 cells. These results indicate that EMT induction promotes CSC traits and cell proportions in the thyroid cancer cells, which implies that EMT could induce cancer stem cell generation and tumor progression in thyroid cancers. Further understanding of the role of EMT and cancer stem cells in cancer progression may reveal new targets for the prevention or therapy of thyroid cancers.

UI MeSH Term Description Entries
D009361 Neoplasm Invasiveness Ability of neoplasms to infiltrate and actively destroy surrounding tissue. Invasiveness, Neoplasm,Neoplasm Invasion,Invasion, Neoplasm
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013964 Thyroid Neoplasms Tumors or cancer of the THYROID GLAND. Cancer of Thyroid,Thyroid Cancer,Cancer of the Thyroid,Neoplasms, Thyroid,Thyroid Adenoma,Thyroid Carcinoma,Adenoma, Thyroid,Adenomas, Thyroid,Cancer, Thyroid,Cancers, Thyroid,Carcinoma, Thyroid,Carcinomas, Thyroid,Neoplasm, Thyroid,Thyroid Adenomas,Thyroid Cancers,Thyroid Carcinomas,Thyroid Neoplasm
D014411 Neoplastic Stem Cells Highly proliferative, self-renewing, and colony-forming stem cells which give rise to NEOPLASMS. Cancer Stem Cells,Colony-Forming Units, Neoplastic,Stem Cells, Neoplastic,Tumor Stem Cells,Neoplastic Colony-Forming Units,Tumor Initiating Cells,Cancer Stem Cell,Cell, Cancer Stem,Cell, Neoplastic Stem,Cell, Tumor Initiating,Cell, Tumor Stem,Cells, Cancer Stem,Cells, Neoplastic Stem,Cells, Tumor Initiating,Cells, Tumor Stem,Colony Forming Units, Neoplastic,Colony-Forming Unit, Neoplastic,Initiating Cell, Tumor,Initiating Cells, Tumor,Neoplastic Colony Forming Units,Neoplastic Colony-Forming Unit,Neoplastic Stem Cell,Stem Cell, Cancer,Stem Cell, Neoplastic,Stem Cell, Tumor,Stem Cells, Cancer,Stem Cells, Tumor,Tumor Initiating Cell,Tumor Stem Cell,Unit, Neoplastic Colony-Forming,Units, Neoplastic Colony-Forming
D015820 Cadherins Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body. Cadherin,E-Cadherins,Epithelial-Cadherin,Liver Cell Adhesion Molecules,N-Cadherins,Neural Cadherin,P-Cadherins,Uvomorulin,Cadherin-1,Cadherin-2,Cadherin-3,E-Cadherin,Epithelial-Cadherins,Liver Cell Adhesion Molecule,N-Cadherin,Neural Cadherins,P-Cadherin,Placental Cadherins,Cadherin 1,Cadherin 2,Cadherin 3,Cadherin, Neural,Cadherins, Neural,Cadherins, Placental,E Cadherin,E Cadherins,Epithelial Cadherin,Epithelial Cadherins,N Cadherin,N Cadherins,P Cadherin,P Cadherins
D015972 Gene Expression Regulation, Neoplastic Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue. Neoplastic Gene Expression Regulation,Regulation of Gene Expression, Neoplastic,Regulation, Gene Expression, Neoplastic
D045744 Cell Line, Tumor A cell line derived from cultured tumor cells. Tumor Cell Line,Cell Lines, Tumor,Line, Tumor Cell,Lines, Tumor Cell,Tumor Cell Lines
D051792 Basic Helix-Loop-Helix Transcription Factors A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF. Basic Helix-Loop-Helix Transcription Factor,bHLH Protein,bHLH Transcription Factor,bHLH Proteins,bHLH Transcription Factors,Basic Helix Loop Helix Transcription Factor,Basic Helix Loop Helix Transcription Factors,Factor, bHLH Transcription,Protein, bHLH,Transcription Factor, bHLH,Transcription Factors, bHLH
D058750 Epithelial-Mesenchymal Transition Phenotypic changes of EPITHELIAL CELLS to MESENCHYME type, which increase cell mobility critical in many developmental processes such as NEURAL TUBE development. NEOPLASM METASTASIS and DISEASE PROGRESSION may also induce this transition. Epithelial-Mesenchymal Transformation,Epithelial Mesenchymal Transformation,Epithelial Mesenchymal Transition,Transformation, Epithelial-Mesenchymal,Transition, Epithelial-Mesenchymal
D063646 Carcinogenesis The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years. Tumorigenesis,Oncogenesis,Carcinogeneses,Oncogeneses,Tumorigeneses

Related Publications

Ling Lan, and Yong Luo, and Dai Cui, and Bing-Yin Shi, and Wei Deng, and Li-Li Huo, and Hai-Ling Chen, and Guo-Ying Zhang, and Li-Li Deng
September 2013, Human pathology,
Ling Lan, and Yong Luo, and Dai Cui, and Bing-Yin Shi, and Wei Deng, and Li-Li Huo, and Hai-Ling Chen, and Guo-Ying Zhang, and Li-Li Deng
August 2008, PloS one,
Ling Lan, and Yong Luo, and Dai Cui, and Bing-Yin Shi, and Wei Deng, and Li-Li Huo, and Hai-Ling Chen, and Guo-Ying Zhang, and Li-Li Deng
October 2011, BMC cancer,
Ling Lan, and Yong Luo, and Dai Cui, and Bing-Yin Shi, and Wei Deng, and Li-Li Huo, and Hai-Ling Chen, and Guo-Ying Zhang, and Li-Li Deng
June 2016, eLife,
Ling Lan, and Yong Luo, and Dai Cui, and Bing-Yin Shi, and Wei Deng, and Li-Li Huo, and Hai-Ling Chen, and Guo-Ying Zhang, and Li-Li Deng
January 2022, Advances in experimental medicine and biology,
Ling Lan, and Yong Luo, and Dai Cui, and Bing-Yin Shi, and Wei Deng, and Li-Li Huo, and Hai-Ling Chen, and Guo-Ying Zhang, and Li-Li Deng
January 2013, Zhonghua bing li xue za zhi = Chinese journal of pathology,
Ling Lan, and Yong Luo, and Dai Cui, and Bing-Yin Shi, and Wei Deng, and Li-Li Huo, and Hai-Ling Chen, and Guo-Ying Zhang, and Li-Li Deng
November 2011, The Journal of biological chemistry,
Ling Lan, and Yong Luo, and Dai Cui, and Bing-Yin Shi, and Wei Deng, and Li-Li Huo, and Hai-Ling Chen, and Guo-Ying Zhang, and Li-Li Deng
August 2016, Genetics and molecular research : GMR,
Ling Lan, and Yong Luo, and Dai Cui, and Bing-Yin Shi, and Wei Deng, and Li-Li Huo, and Hai-Ling Chen, and Guo-Ying Zhang, and Li-Li Deng
June 2015, Journal of cellular physiology,
Ling Lan, and Yong Luo, and Dai Cui, and Bing-Yin Shi, and Wei Deng, and Li-Li Huo, and Hai-Ling Chen, and Guo-Ying Zhang, and Li-Li Deng
April 2010, Cancer research,
Copied contents to your clipboard!