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Application of cyclodextrin-modified gold nanoparticles in enantioselective monolith capillary electrochromatography. 2013

Min Li, and Musa Tarawally, and Xi Liu, and Xiaoling Liu, and Liping Guo, and Li Yang, and Guang Wang
Faculty of Chemistry, Northeast Normal University, Changchun, Jilin, PR China.

β-cyclodextrin modified gold nanoparticles (CD-GNP) were employed as the stationary phase in monolith capillary electrochromatography (CEC) to facilitate enantioseparation. CD-GNP were covalently bound to the surface of the thiolated porous polymer monolithic column. The fabricated enantioselective monolithic column was characterized by a variety of spectroscopic methods. The column exhibited steady EOF mobility over pH values ranging from 4.6 to 9.7. Additionally, the column was stable under CEC separation conditions over 180 min. Moreover, the column exhibited good column-to-column reproducibility. The CD-GNP-modified monolithic column was employed in the efficient CEC separation of three pairs of drug enantiomers (chlorpheniramine, zopiclone and tropicamide). The results exhibit reproducible run-to-run enantioseparations and the monolith column can maintain its enantioselectivity for more than 1 month if the column is stored in a CD-GNP solution at 4°C.

UI MeSH Term Description Entries
D003505 Cyclodextrins A homologous group of cyclic GLUCANS consisting of alpha-1,4 bound glucose units obtained by the action of cyclodextrin glucanotransferase on starch or similar substrates. The enzyme is produced by certain species of Bacillus. Cyclodextrins form inclusion complexes with a wide variety of substances. Cycloamylose,Cyclodextrin,Cyclodextrin Derivatives,Cyclomaltooligosaccharides,Derivatives, Cyclodextrin
D005591 Chemical Fractionation Separation of a mixture in successive stages, each stage removing from the mixture some proportion of one of the substances, for example by differential solubility in water-solvent mixtures. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Fractionation, Chemical,Chemical Fractionations,Fractionations, Chemical
D006046 Gold A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.
D013237 Stereoisomerism The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed) Molecular Stereochemistry,Stereoisomers,Stereochemistry, Molecular,Stereoisomer
D015203 Reproducibility of Results The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results. Reliability and Validity,Reliability of Result,Reproducibility Of Result,Reproducibility of Finding,Validity of Result,Validity of Results,Face Validity,Reliability (Epidemiology),Reliability of Results,Reproducibility of Findings,Test-Retest Reliability,Validity (Epidemiology),Finding Reproducibilities,Finding Reproducibility,Of Result, Reproducibility,Of Results, Reproducibility,Reliabilities, Test-Retest,Reliability, Test-Retest,Result Reliabilities,Result Reliability,Result Validities,Result Validity,Result, Reproducibility Of,Results, Reproducibility Of,Test Retest Reliability,Validity and Reliability,Validity, Face
D044367 Phase Transition A change of a substance from one form or state to another. Gas-Liquid-Solid Phase Transitions,Sol-Gel Phase Transition,Gas Liquid Solid Phase Transitions,Gas-Liquid-Solid Phase Transition,Phase Transition, Gas-Liquid-Solid,Phase Transition, Sol-Gel,Phase Transitions,Phase Transitions, Gas-Liquid-Solid,Phase Transitions, Sol-Gel,Sol Gel Phase Transition,Sol-Gel Phase Transitions,Transition, Gas-Liquid-Solid Phase,Transition, Sol-Gel Phase,Transitions, Gas-Liquid-Solid Phase,Transitions, Sol-Gel Phase
D053758 Nanoparticles Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging. Nanocrystalline Materials,Nanocrystals,Material, Nanocrystalline,Materials, Nanocrystalline,Nanocrystal,Nanocrystalline Material,Nanoparticle
D053768 Metal Nanoparticles Nanoparticles produced from metals whose uses include biosensors, optics, and catalysts. In biomedical applications the particles frequently involve the noble metals, especially gold and silver. Metal Nanocrystals,Metallic Nanocrystals,Metallic Nanoparticles,Metal Nanocrystal,Metal Nanoparticle,Metallic Nanocrystal,Metallic Nanoparticle,Nanocrystal, Metal,Nanocrystal, Metallic,Nanocrystals, Metal,Nanocrystals, Metallic,Nanoparticle, Metal,Nanoparticle, Metallic,Nanoparticles, Metal,Nanoparticles, Metallic
D053801 Capillary Electrochromatography A separation technique which combines LIQUID CHROMATOGRAPHY and CAPILLARY ELECTROPHORESIS. Chip Electrochromatography,Electrochromatography, Capillary,Capillary Electrochromatographies,Electrochromatography, Chip

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