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Association between osteoprotegerin genetic variants and bone mineral density in Chinese women. 2013

Lianbing Shen, and Yihua Qiu, and Shunming Xing, and Dechun Chen, and Yazhong Zhu, and Xiang He, and Jinxin Wang, and Jing Lai, and Guohua Shi, and Teng Liao, and Junming Tan
Center of Trauma Repair and Reconstruction of Chinese PLA and Department of Orthopedics, the 98th Military Hospital, Huzhou 313000, Zhejiang Province, People's Republic of China.

Osteoprotegerin gene (OPG) is one of the most important candidate genes for osteoporosis. The aim of this study was to assess the association between the single nucleotide polymorphisms (SNPs) of OPG gene and bone mineral density (BMD). A total of 706 Chinese postmenopausal women were enrolled in this study. OPG gene variants were genotyped through created restriction site-polymerase chain reaction (CRS-PCR) and verified using DNA sequencing methods. The lumbar spine (L2-4), total hip and femoral neck were evaluated for BMD. Two genetic variants (g.18910G>A and g.27406C>T) were detected in this study. Our data indicated that the significant differences of spine BMD, neck hip BMD and total hip BMD were detected among different g.27406C>T genotype, subjects with the genotype CC were significantly higher than those of genotype CT and TT. However, the g.18910G>A polymorphism was not significantly associated with spine BMD, neck hip BMD and total hip BMD in the studied subjects. Results from this study indicated that OPG gene variants were associated with BMD in Chinese postmenopausal women. These findings will be useful to analyze the role of OPG gene in osteoporosis in the further studies.

UI MeSH Term Description Entries
D008159 Lumbar Vertebrae VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE. Vertebrae, Lumbar
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D005260 Female Females
D005272 Femur Neck The constricted portion of the thigh bone between the femur head and the trochanters. Femoral Neck,Neck, Femoral,Neck, Femur
D005838 Genotype The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. Genogroup,Genogroups,Genotypes
D006615 Hip The projecting part on each side of the body, formed by the side of the pelvis and the top portion of the femur. Coxa,Coxas,Hips
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D015519 Bone Density The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS. Bone Mineral Content,Bone Mineral Density,Bone Densities,Bone Mineral Contents,Bone Mineral Densities,Density, Bone,Density, Bone Mineral
D017698 Postmenopause The physiological period following the MENOPAUSE, the permanent cessation of the menstrual life. Post-Menopause,Post-menopausal Period,Postmenopausal Period,Period, Post-menopausal,Period, Postmenopausal,Post Menopause,Post menopausal Period,Post-Menopauses

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