-transparent.png){kind=logo}
A high-performance liquid chromatographic method was developed for determination of the platelet activating factor antagonist CV-3988 in human plasma and urine. After development of a column extraction procedure without an internal standard, a more satisfactory organic extraction procedure was set up with amiodarone as internal standard. Linearity of the calibration curves was found in the range 0.0625-10 micrograms/ml CV-3988. Reproducibility was higher than 10% for the column extraction and lower than 10% for the organic extraction procedure. Recovery of CV-3988 from plasma averaged 81.7% for the column procedure and 40% for the organic extraction. Urine samples could be extracted only by the organic extraction procedure. The organic extraction procedure was applied to the determination of CV-3988 in plasma and urine samples after intravenous administration to normal volunteers.
R Verbesselt, and
T B Tjandra-Maga, and
P J De Schepper, and
K Itakura, and
T Sugiro
April 1983,
Life sciences,
R Verbesselt, and
T B Tjandra-Maga, and
P J De Schepper, and
K Itakura, and
T Sugiro
June 1987,
Japanese journal of pharmacology,
R Verbesselt, and
T B Tjandra-Maga, and
P J De Schepper, and
K Itakura, and
T Sugiro
January 1986,
Thrombosis research,
R Verbesselt, and
T B Tjandra-Maga, and
P J De Schepper, and
K Itakura, and
T Sugiro
May 1986,
European journal of pharmacology,
R Verbesselt, and
T B Tjandra-Maga, and
P J De Schepper, and
K Itakura, and
T Sugiro
January 1986,
Circulatory shock,
R Verbesselt, and
T B Tjandra-Maga, and
P J De Schepper, and
K Itakura, and
T Sugiro
October 1991,
The Annals of thoracic surgery,
R Verbesselt, and
T B Tjandra-Maga, and
P J De Schepper, and
K Itakura, and
T Sugiro
November 1986,
Chemical & pharmaceutical bulletin,
R Verbesselt, and
T B Tjandra-Maga, and
P J De Schepper, and
K Itakura, and
T Sugiro
May 1990,
Journal of pharmacobio-dynamics,
R Verbesselt, and
T B Tjandra-Maga, and
P J De Schepper, and
K Itakura, and
T Sugiro
March 1992,
The Journal of trauma,
R Verbesselt, and
T B Tjandra-Maga, and
P J De Schepper, and
K Itakura, and
T Sugiro
May 1985,
Biochemical pharmacology,
