Dopamine on D2-like receptors "reboosts" dopamine D1-like receptor-mediated behavioural activation in rats licking for a isotonic NaCl solution. 2013

Adriana Galistu, and Paolo S D'Aquila
Dipartimento di Scienze Biomediche, Università di Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.

BACKGROUND We recently suggested that dopamine on D1-like receptors is involved in the activation of goal-directed responses and the level of response activation is "reboosted" on the basis of an evaluation process involving D2-like receptors assessing "response efficacy". A main piece of evidence in support of this hypothesis was the observation of an "extinction mimicry" effect in the time course of licking bursts after dopamine D2-like receptor blockade in rats licking for sucrose. OBJECTIVE The aim of this study was to determine whether the pattern of licking observed with sucrose as a reward could be reproduced in rats licking for a different reward (0.9% NaCl). METHODS We investigated the effects of the dopamine D1-like receptor antagonist SCH 23390 (0.01-0.04 mg/kg) and of the dopamine D2-like receptor antagonist raclopride (0.025-0.25 mg/kg) on the microstructure of licking for a 0.9% NaCl solution in 12-h water-deprived rats in 30-min sessions. RESULTS As previously observed with sucrose as a reward, raclopride reduced the size of licking bursts and produced on the burst number time course an "extinction mimicry" effect, while SCH 23390 reduced licking exclusively by reducing burst number. CONCLUSIONS These results are consistent with the proposed hypothesis and provide support to the use of the study of licking microstructure as a valid model not only for the investigation of the mechanisms governing ingestive behaviour but also for the investigation of the mechanisms underlying behavioural activation and the related evaluation processes.

UI MeSH Term Description Entries
D008297 Male Males
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004327 Drinking Behavior Behaviors associated with the ingesting of water and other liquids; includes rhythmic patterns of drinking (time intervals - onset and duration), frequency and satiety. Behavior, Drinking,Behaviors, Drinking,Drinking Behaviors
D004347 Drug Interactions The action of a drug that may affect the activity, metabolism, or toxicity of another drug. Drug Interaction,Interaction, Drug,Interactions, Drug
D005260 Female Females
D000704 Analysis of Variance A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable. ANOVA,Analysis, Variance,Variance Analysis,Analyses, Variance,Variance Analyses
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001552 Benzazepines Compounds with BENZENE fused to AZEPINES.
D012737 Sex Factors Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances. Factor, Sex,Factors, Sex,Sex Factor
D012965 Sodium Chloride A ubiquitous sodium salt that is commonly used to season food. Sodium Chloride, (22)Na,Sodium Chloride, (24)NaCl

Related Publications

Adriana Galistu, and Paolo S D'Aquila
August 2010, Pharmacology, biochemistry, and behavior,
Adriana Galistu, and Paolo S D'Aquila
October 2009, The international journal of neuropsychopharmacology,
Adriana Galistu, and Paolo S D'Aquila
September 1990, European journal of pharmacology,
Adriana Galistu, and Paolo S D'Aquila
February 1996, Biochemical Society transactions,
Adriana Galistu, and Paolo S D'Aquila
October 2008, Naunyn-Schmiedeberg's archives of pharmacology,
Adriana Galistu, and Paolo S D'Aquila
July 1986, Life sciences,
Adriana Galistu, and Paolo S D'Aquila
February 1999, European journal of pharmacology,
Adriana Galistu, and Paolo S D'Aquila
January 1996, Neurobiology of aging,
Copied contents to your clipboard!