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Description and nomenclature of Neisseria meningitidis capsule locus. 2013
Odile B Harrison, and
Heike Claus, and
Ying Jiang, and
Julia S Bennett, and
Holly B Bratcher, and
Keith A Jolley, and
Craig Corton, and
Rory Care, and
Jan T Poolman, and
Wendell D Zollinger, and
Carl E Frasch, and
David S Stephens, and
Ian Feavers, and
Matthias Frosch, and
Julian Parkhill, and
Ulrich Vogel, and
Michael A Quail, and
Stephen D Bentley, and
Martin C J Maiden
Department of Zoology, University of Oxford, Oxford, UK. odile.harrison@zoo.ox.ac.uk
Pathogenic Neisseria meningitidis isolates contain a polysaccharide capsule that is the main virulence determinant for this bacterium. Thirteen capsular polysaccharides have been described, and nuclear magnetic resonance spectroscopy has enabled determination of the structure of capsular polysaccharides responsible for serogroup specificity. Molecular mechanisms involved in N. meningitidis capsule biosynthesis have also been identified, and genes involved in this process and in cell surface translocation are clustered at a single chromosomal locus termed cps. The use of multiple names for some of the genes involved in capsule synthesis, combined with the need for rapid diagnosis of serogroups commonly associated with invasive meningococcal disease, prompted a requirement for a consistent approach to the nomenclature of capsule genes. In this report, a comprehensive description of all N. meningitidis serogroups is provided, along with a proposed nomenclature, which was presented at the 2012 XVIIIth International Pathogenic Neisseria Conference.
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