Utility of serum thymidine kinase activity measurements for cases of bovine leukosis with difficult clinical diagnoses. 2013

Mohammad Monir Tawfeeq, and Saori Miura, and Noriyuki Horiuchi, and Yoshiyasu Kobayashi, and Hidefumi Furuoka, and Hisashi Inokuma
Department of Clinical Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido 080-8555, Japan.

This study evaluated the clinical usefulness of serum thymidine kinase (TK) activity for diagnosing bovine leukosis cases for which clinical diagnosis was difficult ('BL with difficult diagnosis'). Median TK activity values in 24 'BL with difficult diagnosis' and 36 cattle for which BL was clinically confirmed by cytology findings of enlarged superficial lymph nodes ('clinically confirmed BL') were 36.8 and 39.4 U/l, respectively (no significant difference). The percentage with positive TK activity (> 5.4 U/l) was also similar in both groups (83.3% for 'BL with difficult diagnosis' and 97.2% for 'clinically confirmed BL'). TK activity was significantly higher in cows with 'BL with difficult diagnosis' compared to those with other tumors (N = 13) and those with inflammatory diseases (N = 14). Maximum TK activity in cows with other tumors and inflammatory diseases was not high (< 10 U/l). Median TK activities in cows with other tumors and those with inflammatory diseases were 1.8 and 1.4 IU/l, respectively. Positive TK activity was found in a significantly higher percentage of cows with 'BL with difficult diagnosis' (83.3%) relative to the percentages of cows with other tumors (15.3%) and inflammatory diseases (21.4%). Thus, TK activity is an appropriate marker for detecting BL onset in cows with 'BL with difficult diagnosis' as well as 'clinically confirmed BL' group. While the specificity of TK activity required for BL diagnosis is not clear, simultaneous evaluation of serum lactate dehydrogenase activity may assist in the differential diagnoses of other tumors and inflammatory diseases from BL.

UI MeSH Term Description Entries
D007770 L-Lactate Dehydrogenase A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist. Lactate Dehydrogenase,Dehydrogenase, L-Lactate,Dehydrogenase, Lactate,L Lactate Dehydrogenase
D008198 Lymph Nodes They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system. Lymph Node,Node, Lymph,Nodes, Lymph
D002417 Cattle Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor. Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013937 Thymidine Kinase An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21. Deoxythymidine Kinase,Deoxypyrimidine Kinase,Kinase, Deoxypyrimidine,Kinase, Deoxythymidine,Kinase, Thymidine
D014408 Biomarkers, Tumor Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or BODY FLUIDS. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including HORMONES; ANTIGENS; amino and NUCLEIC ACIDS; ENZYMES; POLYAMINES; and specific CELL MEMBRANE PROTEINS and LIPIDS. Biochemical Tumor Marker,Cancer Biomarker,Carcinogen Markers,Markers, Tumor,Metabolite Markers, Neoplasm,Tumor Biomarker,Tumor Marker,Tumor Markers, Biochemical,Tumor Markers, Biological,Biochemical Tumor Markers,Biological Tumor Marker,Biological Tumor Markers,Biomarkers, Cancer,Marker, Biochemical Tumor,Marker, Biologic Tumor,Marker, Biological Tumor,Marker, Neoplasm Metabolite,Marker, Tumor Metabolite,Markers, Biochemical Tumor,Markers, Biological Tumor,Markers, Neoplasm Metabolite,Markers, Tumor Metabolite,Metabolite Markers, Tumor,Neoplasm Metabolite Markers,Tumor Markers, Biologic,Tumor Metabolite Marker,Biologic Tumor Marker,Biologic Tumor Markers,Biomarker, Cancer,Biomarker, Tumor,Cancer Biomarkers,Marker, Tumor,Markers, Biologic Tumor,Markers, Carcinogen,Metabolite Marker, Neoplasm,Metabolite Marker, Tumor,Neoplasm Metabolite Marker,Tumor Biomarkers,Tumor Marker, Biochemical,Tumor Marker, Biologic,Tumor Marker, Biological,Tumor Markers,Tumor Metabolite Markers
D016583 Enzootic Bovine Leukosis A lymphoid neoplastic disease in cattle caused by the bovine leukemia virus. Enzootic bovine leukosis may take the form of lymphosarcoma, malignant lymphoma, or leukemia but the presence of malignant cells in the blood is not a consistent finding. Bovine Leukemia,Bovine Leukosis,Bovine Lymphoma,Bovine Lymphosarcoma,Leukemia, Bovine,Leukosis, Bovine,Lymphoma, Bovine,Lymphosarcoma, Bovine,Bovine Leukemias,Bovine Leukoses,Bovine Leukoses, Enzootic,Bovine Leukosis, Enzootic,Bovine Lymphomas,Bovine Lymphosarcomas,Enzootic Bovine Leukoses,Leukemias, Bovine,Leukoses, Bovine,Leukoses, Enzootic Bovine,Leukosis, Enzootic Bovine,Lymphomas, Bovine,Lymphosarcomas, Bovine
D018709 Statistics, Nonparametric A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5) Kolmogorov-Smirnov Test,Kruskal-Wallis H Statistic,Mann-Whitney U Test,Rank-Sum Tests,Spearman Rank Correlation Coefficient,Wilcox Test,Wilcoxon Rank Test,Non-Parametric Statistics,Nonparametric Statistics,Statistics, Non-Parametric,Kolmogorov Smirnov Test,Mann Whitney U Test,Non Parametric Statistics,Rank Sum Tests,Rank Test, Wilcoxon,Rank-Sum Test,Statistics, Non Parametric,Test, Kolmogorov-Smirnov,Test, Mann-Whitney U,Test, Rank-Sum,Test, Wilcox,Test, Wilcoxon Rank,Tests, Rank-Sum,U Test, Mann-Whitney

Related Publications

Mohammad Monir Tawfeeq, and Saori Miura, and Noriyuki Horiuchi, and Yoshiyasu Kobayashi, and Hidefumi Furuoka, and Hisashi Inokuma
November 2009, Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc,
Mohammad Monir Tawfeeq, and Saori Miura, and Noriyuki Horiuchi, and Yoshiyasu Kobayashi, and Hidefumi Furuoka, and Hisashi Inokuma
January 2013, BoneKEy reports,
Mohammad Monir Tawfeeq, and Saori Miura, and Noriyuki Horiuchi, and Yoshiyasu Kobayashi, and Hidefumi Furuoka, and Hisashi Inokuma
July 2015, The Journal of veterinary medical science,
Mohammad Monir Tawfeeq, and Saori Miura, and Noriyuki Horiuchi, and Yoshiyasu Kobayashi, and Hidefumi Furuoka, and Hisashi Inokuma
November 2019, BMC veterinary research,
Mohammad Monir Tawfeeq, and Saori Miura, and Noriyuki Horiuchi, and Yoshiyasu Kobayashi, and Hidefumi Furuoka, and Hisashi Inokuma
January 2010, Cancer biomarkers : section A of Disease markers,
Mohammad Monir Tawfeeq, and Saori Miura, and Noriyuki Horiuchi, and Yoshiyasu Kobayashi, and Hidefumi Furuoka, and Hisashi Inokuma
February 2002, Internal medicine (Tokyo, Japan),
Mohammad Monir Tawfeeq, and Saori Miura, and Noriyuki Horiuchi, and Yoshiyasu Kobayashi, and Hidefumi Furuoka, and Hisashi Inokuma
July 1989, Anales de medicina interna (Madrid, Spain : 1984),
Mohammad Monir Tawfeeq, and Saori Miura, and Noriyuki Horiuchi, and Yoshiyasu Kobayashi, and Hidefumi Furuoka, and Hisashi Inokuma
February 1993, Gastroenterologia Japonica,
Mohammad Monir Tawfeeq, and Saori Miura, and Noriyuki Horiuchi, and Yoshiyasu Kobayashi, and Hidefumi Furuoka, and Hisashi Inokuma
September 2012, The Journal of veterinary medical science,
Mohammad Monir Tawfeeq, and Saori Miura, and Noriyuki Horiuchi, and Yoshiyasu Kobayashi, and Hidefumi Furuoka, and Hisashi Inokuma
December 2012, Veterinary and comparative oncology,
Copied contents to your clipboard!