CE verbal episodic memory impairment in schizophrenia: a comparison with frontal lobe lesion patients. 2013

Bruce K Christensen, and Regan E Patrick, and Donald T Stuss, and Susan Gillingham, and Robert B Zipursky
Department of Psychiatry & Behavioural Neuroscience, McMaster University, Hamilton, Ontario, Canada. bruce.christensen@mcmaster.ca

Schizophrenia (SCZ)-related verbal memory impairment is hypothesized to be mediated, in part, by frontal lobe (FTL) dysfunction. However, little research has contrasted the performance of SCZ patients with that of patients exhibiting circumscribed frontal lesions. The current study compared verbal episodic memory in patients with SCZ and focal FTL lesions (left frontal, LF; right frontal, RF; and bi-frontal, BF) on a four-trial list learning task consisting of three lists of varying semantic organizational structure. Each dependent variable was examined at two levels: scores collapsed across all four trials and learning scores (i.e., trial 4-trial 1). Performance deficits were observed in each patient group across most dependent measures at both levels. Regarding patient group differences, SCZ patients outperformed LF/BF patients (i.e., either learning scores or scores collapsed across trial) on free recall, primacy, primary memory, secondary memory, and subjective organization, whereas they only outperformed RF patients on the semantically blocked list on recency and primary memory. Collectively, these results indicate that the pattern of memory performance is largely similar between patients with SCZ and those with RF lesions. These data support tentative arguments that verbal episodic memory deficits in SCZ may be mediated by frontal dysfunction in the right hemisphere.

UI MeSH Term Description Entries
D008297 Male Males
D008569 Memory Disorders Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions. Memory Loss,Age-Related Memory Disorders,Memory Deficits,Memory Disorder, Semantic,Memory Disorder, Spatial,Memory Disorders, Age-Related,Retention Disorders, Cognitive,Semantic Memory Disorder,Spatial Memory Disorder,Age Related Memory Disorders,Age-Related Memory Disorder,Cognitive Retention Disorder,Cognitive Retention Disorders,Deficit, Memory,Deficits, Memory,Memory Deficit,Memory Disorder,Memory Disorder, Age-Related,Memory Disorders, Age Related,Memory Disorders, Semantic,Memory Disorders, Spatial,Memory Losses,Retention Disorder, Cognitive,Semantic Memory Disorders,Spatial Memory Disorders
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009483 Neuropsychological Tests Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury. Aphasia Tests,Cognitive Test,Cognitive Testing,Cognitive Tests,Memory for Designs Test,Neuropsychological Testing,AX-CPT,Behavioral Assessment of Dysexecutive Syndrome,CANTAB,Cambridge Neuropsychological Test Automated Battery,Clock Test,Cognitive Function Scanner,Continuous Performance Task,Controlled Oral Word Association Test,Delis-Kaplan Executive Function System,Developmental Neuropsychological Assessment,Hooper Visual Organization Test,NEPSY,Neuropsychologic Tests,Neuropsychological Test,Paced Auditory Serial Addition Test,Repeatable Battery for the Assessment of Neuropsychological Status,Rey-Osterrieth Complex Figure,Symbol Digit Modalities Test,Test of Everyday Attention,Test, Neuropsychological,Tests, Neuropsychological,Tower of London Test,Neuropsychologic Test,Test, Cognitive,Testing, Cognitive,Testing, Neuropsychological,Tests, Cognitive
D011569 Psychiatric Status Rating Scales Standardized procedures utilizing rating scales or interview schedules carried out by health personnel for evaluating the degree of mental illness. Factor Construct Rating Scales (FCRS),Katz Adjustment Scales,Lorr's Inpatient Multidimensional Psychiatric Rating Scale,Wittenborn Scales,Edinburgh Postnatal Depression Scale,Mini International Neuropsychiatric Interview
D011939 Mental Recall The process whereby a representation of past experience is elicited. Recall, Mental
D005260 Female Females
D005625 Frontal Lobe The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus. Brodmann Area 8,Brodmann's Area 8,Frontal Cortex,Frontal Eye Fields,Lobus Frontalis,Supplementary Eye Field,Area 8, Brodmann,Area 8, Brodmann's,Brodmanns Area 8,Cortex, Frontal,Eye Field, Frontal,Eye Field, Supplementary,Eye Fields, Frontal,Frontal Cortices,Frontal Eye Field,Frontal Lobes,Lobe, Frontal,Supplementary Eye Fields
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

Bruce K Christensen, and Regan E Patrick, and Donald T Stuss, and Susan Gillingham, and Robert B Zipursky
November 1995, Journal of the International Neuropsychological Society : JINS,
Bruce K Christensen, and Regan E Patrick, and Donald T Stuss, and Susan Gillingham, and Robert B Zipursky
November 2006, Cortex; a journal devoted to the study of the nervous system and behavior,
Bruce K Christensen, and Regan E Patrick, and Donald T Stuss, and Susan Gillingham, and Robert B Zipursky
January 1989, Neuropsychologia,
Bruce K Christensen, and Regan E Patrick, and Donald T Stuss, and Susan Gillingham, and Robert B Zipursky
June 2013, Behavioral sciences (Basel, Switzerland),
Bruce K Christensen, and Regan E Patrick, and Donald T Stuss, and Susan Gillingham, and Robert B Zipursky
June 1986, Cortex; a journal devoted to the study of the nervous system and behavior,
Bruce K Christensen, and Regan E Patrick, and Donald T Stuss, and Susan Gillingham, and Robert B Zipursky
November 2013, Schizophrenia research,
Bruce K Christensen, and Regan E Patrick, and Donald T Stuss, and Susan Gillingham, and Robert B Zipursky
January 2015, PloS one,
Bruce K Christensen, and Regan E Patrick, and Donald T Stuss, and Susan Gillingham, and Robert B Zipursky
April 2001, The American journal of psychiatry,
Bruce K Christensen, and Regan E Patrick, and Donald T Stuss, and Susan Gillingham, and Robert B Zipursky
January 2002, Neuropsychologia,
Bruce K Christensen, and Regan E Patrick, and Donald T Stuss, and Susan Gillingham, and Robert B Zipursky
April 1998, Cortex; a journal devoted to the study of the nervous system and behavior,
Copied contents to your clipboard!