-transparent.png){kind=logo}
R-phenylisopropyl-adenosine, which has an affinity for the adenosine A1 receptor higher than that for the A2 receptor, and N-ethylcarboxamide-adenosine, which has near equal affinity for the A1 and A2 receptors, were injected intrathecally into rats to evaluate differences in antinociceptive effect and motor impairment. Using the tail-immersion test, both compounds had antinociceptive effects. Motor function was evaluated during spontaneous movement in a free space. N-ethylcarboxamide-adenosine rapidly impaired motor function even after low intrathecal doses. R-phenylisopropyl-adenosine also induced motor impairment, but only after high intrathecal doses, and onset was much slower. These results suggest that the receptor selectivity of R-phenylisopropyl-adenosine is diminished at higher doses and that the motor impairment is an A2-receptor-mediated effect. A selective A1 receptor agonist, e.g., R-phenylisopropyl-adenosine, which produces a good antinociceptive effect without motor impairment, is more promising as a drug of possible use for the future treatment of clinical pain.
R Karlsten, and
T Gordh, and
P Hartvig, and
C Post
October 1984,
Neuroscience letters,
R Karlsten, and
T Gordh, and
P Hartvig, and
C Post
July 1996,
Neuroreport,
R Karlsten, and
T Gordh, and
P Hartvig, and
C Post
February 1998,
Neuroscience letters,
R Karlsten, and
T Gordh, and
P Hartvig, and
C Post
October 1982,
Science (New York, N.Y.),
R Karlsten, and
T Gordh, and
P Hartvig, and
C Post
May 1997,
Acta anaesthesiologica Scandinavica,
R Karlsten, and
T Gordh, and
P Hartvig, and
C Post
June 1985,
European journal of pharmacology,
R Karlsten, and
T Gordh, and
P Hartvig, and
C Post
October 1988,
Pain,
R Karlsten, and
T Gordh, and
P Hartvig, and
C Post
February 2005,
Acta pharmacologica Sinica,
R Karlsten, and
T Gordh, and
P Hartvig, and
C Post
June 1990,
Brain research,
R Karlsten, and
T Gordh, and
P Hartvig, and
C Post
December 1982,
Neuroscience letters,
