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The release of DNA 5'-terminal deoxyribose-phosphate residues from enzymatically incised apurinic/apyrimidinic sites by human cell extracts has been under investigation. During the course of these studies, we observed that ataxia telangiectasia cell extracts modify deoxyribose-phosphate (dRp) residues by converting them to an altered form, dRp-X, which shows altered chromatographic properties on HPLC analysis. The chemical nature of the adduct is as yet unknown, but dRp-X is stable to both heat and acid. The modification requires an enzymatic activity and a low-molecular weight co-factor. Extracts of normal cells contain a dialyzable inhibitor that suppresses the reaction occurring with ataxia telangiectasia cell extracts. Formation of dRp-X has been observed in 7 out of 7 ataxia telangiectasia lymphoblastoid lines which represent at least 3 genetic complementation groups. Similar modification of dRp did not occur with extracts of cells of normal origin, nor those representing Fanconi's anaemia, xeroderma pigmentosum, Bloom's syndrome, Werner's syndrome or Friedreich's ataxia.
L R Karam, and
P Calsou, and
W A Franklin, and
R B Painter, and
M Olsson, and
T Lindahl
April 1986,
Experimental cell research,
L R Karam, and
P Calsou, and
W A Franklin, and
R B Painter, and
M Olsson, and
T Lindahl
August 1995,
Science (New York, N.Y.),
L R Karam, and
P Calsou, and
W A Franklin, and
R B Painter, and
M Olsson, and
T Lindahl
September 1991,
Biochemistry,
L R Karam, and
P Calsou, and
W A Franklin, and
R B Painter, and
M Olsson, and
T Lindahl
August 2009,
Neurology,
L R Karam, and
P Calsou, and
W A Franklin, and
R B Painter, and
M Olsson, and
T Lindahl
February 1989,
Biochemical and biophysical research communications,
L R Karam, and
P Calsou, and
W A Franklin, and
R B Painter, and
M Olsson, and
T Lindahl
February 2012,
Neuropathology : official journal of the Japanese Society of Neuropathology,
L R Karam, and
P Calsou, and
W A Franklin, and
R B Painter, and
M Olsson, and
T Lindahl
October 1983,
Carcinogenesis,
L R Karam, and
P Calsou, and
W A Franklin, and
R B Painter, and
M Olsson, and
T Lindahl
April 1968,
Bulletin des societes d'ophtalmologie de France,
L R Karam, and
P Calsou, and
W A Franklin, and
R B Painter, and
M Olsson, and
T Lindahl
January 2001,
Advances in experimental medicine and biology,
L R Karam, and
P Calsou, and
W A Franklin, and
R B Painter, and
M Olsson, and
T Lindahl
January 1994,
Ryoikibetsu shokogun shirizu,
