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Friend cells were labelled for 90 min. with [3H]-Glycerol and the radioactivity in DAG# and TG was measured. The relative percentage of radiolabelled DAG differs in isolated nuclei as compared to intact cells. Moreover the level of newly synthesized DAG decreases in nuclei isolated from cells treated with DMSO for 24 hrs. as well as in nuclei from cells treated for 96 hrs. and terminally differentiated in the erythroid pathway. Since these changes are not seen in intact cells, the results are consistent with the hypothesis that nuclear lipids and namely the products of polyphosphoinositide hydrolysis, such as DAG, are involved in the regulation of the processes leading to cell differentiation.
O Trubiani, and
A M Martelli, and
L Manzoli, and
E Santavenere, and
L Cocco
May 1976,
Experimental cell research,
O Trubiani, and
A M Martelli, and
L Manzoli, and
E Santavenere, and
L Cocco
January 1982,
Annali dell'Istituto superiore di sanita,
O Trubiani, and
A M Martelli, and
L Manzoli, and
E Santavenere, and
L Cocco
December 1977,
Cell differentiation,
O Trubiani, and
A M Martelli, and
L Manzoli, and
E Santavenere, and
L Cocco
September 1990,
Cell biology international reports,
O Trubiani, and
A M Martelli, and
L Manzoli, and
E Santavenere, and
L Cocco
December 1978,
Biochemical and biophysical research communications,
O Trubiani, and
A M Martelli, and
L Manzoli, and
E Santavenere, and
L Cocco
January 1979,
Haematology and blood transfusion,
O Trubiani, and
A M Martelli, and
L Manzoli, and
E Santavenere, and
L Cocco
January 1975,
Bibliotheca haematologica,
O Trubiani, and
A M Martelli, and
L Manzoli, and
E Santavenere, and
L Cocco
April 1982,
Journal of cell science,
O Trubiani, and
A M Martelli, and
L Manzoli, and
E Santavenere, and
L Cocco
March 1978,
Journal of cellular physiology,
O Trubiani, and
A M Martelli, and
L Manzoli, and
E Santavenere, and
L Cocco
January 1980,
Experimental cell research,
