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The alpha B-crystallin gene (CRYA2) encodes the abundant lens protein alpha B-crystallin. A panel of human/rodent hybrid cell lines, derived from five different parental combinations, was characterized with respect to human chromosomal content and the presence of well-established human chromosome-specific markers. This panel was screened for the presence of CRYA2, using the third exon of the hamster alpha B-crystallin gene as a probe. The patterns of segregation of CRYA2 with individual human chromosomes show the highest degree of concordance between CRYA2 and chromosome 11. Using cell hybrids containing translocated and/or partially deleted human chromosomes, the CRYA2 gene was localized to 11q12-11q23.
R H Brakenhoff, and
A H Guerts van Kessel, and
M Oldenburg, and
J T Wijnen, and
H Bloemendal, and
P Meera Khan, and
J G Schoenmakers
November 1989,
Genomics,
R H Brakenhoff, and
A H Guerts van Kessel, and
M Oldenburg, and
J T Wijnen, and
H Bloemendal, and
P Meera Khan, and
J G Schoenmakers
January 1999,
Ryoikibetsu shokogun shirizu,
R H Brakenhoff, and
A H Guerts van Kessel, and
M Oldenburg, and
J T Wijnen, and
H Bloemendal, and
P Meera Khan, and
J G Schoenmakers
October 1986,
Human genetics,
R H Brakenhoff, and
A H Guerts van Kessel, and
M Oldenburg, and
J T Wijnen, and
H Bloemendal, and
P Meera Khan, and
J G Schoenmakers
April 1999,
Genomics,
R H Brakenhoff, and
A H Guerts van Kessel, and
M Oldenburg, and
J T Wijnen, and
H Bloemendal, and
P Meera Khan, and
J G Schoenmakers
December 1991,
Genomics,
R H Brakenhoff, and
A H Guerts van Kessel, and
M Oldenburg, and
J T Wijnen, and
H Bloemendal, and
P Meera Khan, and
J G Schoenmakers
August 2000,
Animal genetics,
R H Brakenhoff, and
A H Guerts van Kessel, and
M Oldenburg, and
J T Wijnen, and
H Bloemendal, and
P Meera Khan, and
J G Schoenmakers
November 1990,
Genomics,
R H Brakenhoff, and
A H Guerts van Kessel, and
M Oldenburg, and
J T Wijnen, and
H Bloemendal, and
P Meera Khan, and
J G Schoenmakers
July 2001,
Immunogenetics,
R H Brakenhoff, and
A H Guerts van Kessel, and
M Oldenburg, and
J T Wijnen, and
H Bloemendal, and
P Meera Khan, and
J G Schoenmakers
June 1993,
JAMA,
R H Brakenhoff, and
A H Guerts van Kessel, and
M Oldenburg, and
J T Wijnen, and
H Bloemendal, and
P Meera Khan, and
J G Schoenmakers
June 1997,
American journal of human genetics,
