-transparent.png){kind=logo}
1,25-dihydroxyvitamin D3 (1,25(OH)2D3) dose-dependently inhibited the cytotoxicity of tumor necrosis factor (TNF) in a human monoblastic leukemic cell line, U-937. Combination of TNF and 1,25(OH)2D3 remarkably increased mitochondrial superoxide dismutase (mSOD) of U-937 cells, TNF alone increased it only slightly and 1,25(OH)2D3 alone did not. The cytosolic SOD (cSOD) activity was not changed by TNF or/and 1,25(OH)2D3. The mSOD activity was not inhibited by 2 mM KCN, suggesting that mSOD should be a manganese SOD (MnSOD). These results suggest that 1,25(OH)2D3 may reduce the susceptibility to TNF cytotoxicity of U-937 cells by enhancing the ability of inducing MnSOD by TNF.
S Iwamoto, and
K Takeda, and
R Kamijo, and
K Konno
January 1988,
Thrombosis research. Supplement,
S Iwamoto, and
K Takeda, and
R Kamijo, and
K Konno
August 2000,
Endocrine journal,
S Iwamoto, and
K Takeda, and
R Kamijo, and
K Konno
February 1989,
Cellular immunology,
S Iwamoto, and
K Takeda, and
R Kamijo, and
K Konno
December 1986,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
S Iwamoto, and
K Takeda, and
R Kamijo, and
K Konno
April 1995,
Experimental cell research,
S Iwamoto, and
K Takeda, and
R Kamijo, and
K Konno
March 1985,
Endocrinology,
S Iwamoto, and
K Takeda, and
R Kamijo, and
K Konno
May 1984,
Cancer research,
S Iwamoto, and
K Takeda, and
R Kamijo, and
K Konno
June 1992,
Experimental cell research,
S Iwamoto, and
K Takeda, and
R Kamijo, and
K Konno
March 1974,
Science (New York, N.Y.),
S Iwamoto, and
K Takeda, and
R Kamijo, and
K Konno
December 1994,
Molecular and cellular endocrinology,
