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Immunomodulation of the tumor microenvironment by Toll-like receptor-3 (TLR3) ligands. 2013

Valerie Chew, and Jean-Pierre Abastado
Singapore Immunology Network (SIgN); Agency for Science Technology and Research (ASTAR); 8A Biomedical Grove; Immunos; Biopolis, Singapore.

In hepatocellular carcinoma (HCC) patients, the intratumoral expression of Toll-like receptor-3 (TLR3) correlates with prolonged survival. We demonstrated that TLR3 ligands can operate through three independent mechanisms: by directly killing TLR3-expressing cancer cells, by inducing T- and natural killer (NK)-cell infiltration and by activating TLR3-expressing NK cells.

UI MeSH Term Description Entries

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