Biomaterial Database

[Effects of cepharanthine on liposomal permeability and size]. 1990

K Shinoda, and I Adachi, and M Ueno, and I Horikoshi

Department of Hospital Pharmacy, Toyama Medical and Pharmaceutical University, Japan.

Effects of cepharanthine, one of membrane-stabilizing agents, on membrane permeability and on liposomal size were examined. When cepharanthine was added to the lipid before liposome formation, the size of liposome increased and the permeability did not change. On the other hand, when cepharanthine was added to the liposome suspension after liposome formation, no effect was found on liposomal size but the membrane permeability increased and lag time of initial leak of 5 (& 6)-carboxyfluorescein reduced dose-dependently.

UI	MeSH Term	Description	Entries
D008081	Liposomes	Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.	Niosomes,Transferosomes,Ultradeformable Liposomes,Liposomes, Ultra-deformable,Liposome,Liposome, Ultra-deformable,Liposome, Ultradeformable,Liposomes, Ultra deformable,Liposomes, Ultradeformable,Niosome,Transferosome,Ultra-deformable Liposome,Ultra-deformable Liposomes,Ultradeformable Liposome
D010316	Particle Size	Relating to the size of solids.	Particle Sizes,Size, Particle,Sizes, Particle
D002463	Cell Membrane Permeability	A quality of cell membranes which permits the passage of solvents and solutes into and out of cells.	Permeability, Cell Membrane
D000470	Alkaloids	Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)	Alkaloid,Plant Alkaloid,Plant Alkaloids,Alkaloid, Plant,Alkaloids, Plant
D044182	Benzylisoquinolines	ISOQUINOLINES with a benzyl substituent.	Benzyl-Isoquinoline,Benzylisoquinoline,Bis-Benzyl-Isoquinoline,Bis-Benzylisoquinoline,Bisbenzylisoquinoline,Bisbenzylisoquinolines,Benzyl-Isoquinolines,Bis-Benzyl-Isoquinolines,Bis-Benzylisoquinolines,Benzyl Isoquinoline,Benzyl Isoquinolines,Bis Benzyl Isoquinoline,Bis Benzyl Isoquinolines,Bis Benzylisoquinoline,Bis Benzylisoquinolines