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MicroRNAs: Novel diagnostic and prognostic biomarkers in atherosclerosis. 2013
Gerasimos Siasos, and
Christina Kollia, and
Vasiliki Tsigkou, and
Efthimia K Basdra, and
Maria Lymperi, and
Evangelos Oikonomou, and
Eleni Kokkou, and
Porfyrios Korompelis, and
Athanasios G Papavassiliou
Department of Biological Chemistry, University of Athens Medical School, Athens Greece. gsiasos@med.uoa.gr
MicroRNAs (miRNAs) are an emerging class of highly conserved, non-coding small RNAs that regulate gene expression on the post-transcriptional level by inhibiting the translation of protein from mRNA or by promoting the degradation of mRNA. The involvement of miRNAs in the regulation of lipid metabolism, inflammatory response, cell cycle progression and proliferation, oxidative stress, platelet activation, endothelial function, angiogenesis and plaque formation and rapture indicates important roles in the initiation and progression of atherosclerosis. In the light of this evidence we will review the role of miRNAs in atherosclerosis.
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