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The localization of 3 major types of protein kinase C (PKC) was immunohistochemically studied in human brain using monoclonal antibodies raised against each of the types. Immunoreactivity for type I was observed in neuronal cells in cerebrum and Purkinje cells in cerebellum. Immunoreactivity for type II was mainly observed in neuropil of cerebral cortex and in the molecular and granular layers of cerebellum. Occasional neurons in cerebrum were also stained. Immunoreactivity for type III was almost exclusively localized in astrocytes in gray and white matter, subpial astrocytes, and cerebellar Bergmann's glia. The present study suggests that the type III of PKC is preferentially expressed in astrocytes in human brain.
T Todo, and
N Shitara, and
H Nakamura, and
K Takakura, and
M Tomonaga, and
K Ikeda
March 1994,
Digestive diseases and sciences,
T Todo, and
N Shitara, and
H Nakamura, and
K Takakura, and
M Tomonaga, and
K Ikeda
April 1989,
Journal of cellular biochemistry,
T Todo, and
N Shitara, and
H Nakamura, and
K Takakura, and
M Tomonaga, and
K Ikeda
January 1990,
Acta dermato-venereologica,
T Todo, and
N Shitara, and
H Nakamura, and
K Takakura, and
M Tomonaga, and
K Ikeda
October 1989,
Brain research,
T Todo, and
N Shitara, and
H Nakamura, and
K Takakura, and
M Tomonaga, and
K Ikeda
March 1990,
The Journal of biological chemistry,
T Todo, and
N Shitara, and
H Nakamura, and
K Takakura, and
M Tomonaga, and
K Ikeda
April 1993,
Neurosurgery,
T Todo, and
N Shitara, and
H Nakamura, and
K Takakura, and
M Tomonaga, and
K Ikeda
February 1990,
Neuroscience research,
T Todo, and
N Shitara, and
H Nakamura, and
K Takakura, and
M Tomonaga, and
K Ikeda
January 1989,
Genomics,
T Todo, and
N Shitara, and
H Nakamura, and
K Takakura, and
M Tomonaga, and
K Ikeda
November 1994,
Biochemical and biophysical research communications,
T Todo, and
N Shitara, and
H Nakamura, and
K Takakura, and
M Tomonaga, and
K Ikeda
May 1992,
Archives of biochemistry and biophysics,
