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We have assessed the natural killer (NK) cell-mediated cytotoxicity and antibody-dependent cellular cytotoxicity (ADCC) in the peripheral blood lymphocytes (PBL) from untreated lepromatous leprosy (LL) patients, LL patients on multidrug therapy (MDT) with favorable responses (MDT-R), LL patients clinically classified as nonresponders to MDT (MDT-NR), treated tuberculoid leprosy (TT) patients, and healthy donors. NK cytotoxicity was modulated by treating the PBL with recombinant interferon-alpha (IFN-alpha) and recombinant interleukin-2 (IL-2). The mean percent NK cytotoxicity of untreated LL patients (15 +/- 3), treated MDT-R patients (20 +/- 4), and treated MDT-NR patients (12 +/- 4) was significantly lower than that of TT patients (39 +/- 6) and healthy donors (37 +/- 5). Treatment of effectors with IL-2 or IFN-alpha enhanced NK cytotoxicity in 5 of 6 untreated LL patients, 6 of 6 treated MDT-R LL patients, 4 of 5 and 3 of 5 treated MDT-NR LL patients, respectively, and 5 of 8 and 3 of 8 treated TT patients, respectively. Although PBL from TT patients showed initial NK activity comparable to that of healthy donors, fewer TT patients showed modulation of NK activity by IL-2, and IFN-alpha to a lesser extent. The ADCC activity was lower in untreated LL patients compared to treated patients, while TT patients had normal ADCC activity. The results indicate that although LL patients show lowered spontaneous cytotoxicity, it can be modulated favorably by lymphokines.
S V Chiplunkar, and
M V Deshmukh, and
P D Samson, and
R Butlin, and
W S Bhatki, and
R G Chulawalla, and
M G Deo, and
S G Gangal
November 1982,
Journal of the American Veterinary Medical Association,
S V Chiplunkar, and
M V Deshmukh, and
P D Samson, and
R Butlin, and
W S Bhatki, and
R G Chulawalla, and
M G Deo, and
S G Gangal
January 2013,
Frontiers in immunology,
S V Chiplunkar, and
M V Deshmukh, and
P D Samson, and
R Butlin, and
W S Bhatki, and
R G Chulawalla, and
M G Deo, and
S G Gangal
November 1986,
Journal of reproductive immunology,
S V Chiplunkar, and
M V Deshmukh, and
P D Samson, and
R Butlin, and
W S Bhatki, and
R G Chulawalla, and
M G Deo, and
S G Gangal
May 1982,
Acta paediatrica Scandinavica,
S V Chiplunkar, and
M V Deshmukh, and
P D Samson, and
R Butlin, and
W S Bhatki, and
R G Chulawalla, and
M G Deo, and
S G Gangal
December 1985,
Japanese journal of clinical oncology,
S V Chiplunkar, and
M V Deshmukh, and
P D Samson, and
R Butlin, and
W S Bhatki, and
R G Chulawalla, and
M G Deo, and
S G Gangal
September 1988,
Biochemical and biophysical research communications,
S V Chiplunkar, and
M V Deshmukh, and
P D Samson, and
R Butlin, and
W S Bhatki, and
R G Chulawalla, and
M G Deo, and
S G Gangal
January 1986,
Developmental and comparative immunology,
S V Chiplunkar, and
M V Deshmukh, and
P D Samson, and
R Butlin, and
W S Bhatki, and
R G Chulawalla, and
M G Deo, and
S G Gangal
January 1987,
Clinical nephrology,
S V Chiplunkar, and
M V Deshmukh, and
P D Samson, and
R Butlin, and
W S Bhatki, and
R G Chulawalla, and
M G Deo, and
S G Gangal
January 1986,
Cancer immunology, immunotherapy : CII,
S V Chiplunkar, and
M V Deshmukh, and
P D Samson, and
R Butlin, and
W S Bhatki, and
R G Chulawalla, and
M G Deo, and
S G Gangal
June 2019,
Journal of leukocyte biology,
