Biomaterial Database

[The effect of aspirin, antacids, alcohol, and bile acids on transmural potential difference of the human stomach (author's transl)]. 1975

W F Caspary

The effect of orally administered buffered and unbuffered aspirin, antacids, alcohol and bile salts on functional changes in the gastric mucosal barrier was assessed by measuring gastric transmural potential differences (PD) in healthy subjects. In contrast to buffered aspirin, unbuffered aspirin caused a marked decrease in transmural PD due to its known effect of enhancing H+ back-diffusion. Simultaneous administration of antacids prevented the aspirin-induced drop of transmural PD. Ethanol (20% w/v), whisky (45% w/v), wine (6-7% ethanol), bile salts and ox-bile reduced transmural PD in healthy subjects. The measurement of transmural PD is a simple and sensitive method for detecting functional changes in the gastric mucosal barrier induced by drugs known to alter mucosal permeability.

UI	MeSH Term	Description	Entries
D010539	Permeability	Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.	Permeabilities
D002021	Buffers	A chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer.	Buffer
D004560	Electricity	The physical effects involving the presence of electric charges at rest and in motion.
D005745	Gastric Acidity Determination	Gastric analysis for determination of free acid or total acid.	Acidity Determination, Gastric,Acidity Determinations, Gastric,Determination, Gastric Acidity,Determinations, Gastric Acidity,Gastric Acidity Determinations
D005750	Gastric Juice	The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651)	Gastric Juices,Juice, Gastric,Juices, Gastric
D005753	Gastric Mucosa	Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.	Cardiac Glands,Gastric Glands,Pyloric Glands,Cardiac Gland,Gastric Gland,Gastric Mucosas,Gland, Cardiac,Gland, Gastric,Gland, Pyloric,Glands, Cardiac,Glands, Gastric,Glands, Pyloric,Mucosa, Gastric,Mucosas, Gastric,Pyloric Gland
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006863	Hydrogen-Ion Concentration	The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH	pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations
D000431	Ethanol	A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.	Alcohol, Ethyl,Absolute Alcohol,Grain Alcohol,Alcohol, Absolute,Alcohol, Grain,Ethyl Alcohol
D000863	Antacids	Substances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT.	Alkalinizing Agent,Antacid,Alkalinizing Agents,Agent, Alkalinizing,Agents, Alkalinizing