Biomaterial Database

New natural filarial parasites of nonhuman primates in Kenya: a potential use as laboratory model/s for onchocerciasis. 1990

C N Wamae, and F O Odongo

Kenya Medical Research Institute, Centre for Microbiology Research, Nairobi.

To determine the natural filarial infections in east african nonhuman primates, we initiated a screening study at the Institute of Primate Research (IPR) in 1985. We report the findings of this study for the period between 1985 and 1988. Animals screened were wild-caught from different geographical regions of Kenya for various biomedical studies at IPR. We have recovered three dermal filariae from the animals. Two of these parasites are new and have never been described before. Based on demonstratable microfilariae (mf) there was a total infection rate of 67.10%. The adult stages of these filariae are dermal while the free-living mf live in the skin. Our attempts to transmit these infections to tick vectors have been unsuccessful inspite of tick attachment and engorgement. A susceptible vector remains to be determined.

UI	MeSH Term	Description	Entries
D007630	Kenya	A republic in eastern Africa, south of ETHIOPIA, west of SOMALIA with TANZANIA to its south, and coastline on the Indian Ocean. Its capital is Nairobi.	Republic of Kenya
D009855	Onchocerciasis	Infection with nematodes of the genus ONCHOCERCA. Characteristics include the presence of firm subcutaneous nodules filled with adult worms, PRURITUS, and ocular lesions.	Onchocerciases
D011323	Primates	An order of mammals consisting of more than 300 species that include LEMURS; LORISIDAE; TARSIERS; MONKEYS; and HOMINIDS. They are characterized by a relatively large brain when compared with other terrestrial mammals, forward-facing eyes, the presence of a CALCARINE SULCUS, and specialized MECHANORECEPTORS in the hands and feet which allow the perception of light touch.	Primate
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005368	Filariasis	Infections with nematodes of the superfamily FILARIOIDEA. The presence of living worms in the body is mainly asymptomatic but the death of adult worms leads to granulomatous inflammation and permanent fibrosis. Organisms of the genus Elaeophora infect wild elk and domestic sheep causing ischemic necrosis of the brain, blindness, and dermatosis of the face.	Elaeophoriasis,Filarioidea Infections,Infections, Filarioidea,Elaeophoriases,Filariases,Filarioidea Infection,Infection, Filarioidea
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012867	Skin	The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.