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Recently, long-acting injectable forms of bromocriptine have become available for the prevention of lactation. The first developed depot-form was very effective, but had the disadvantage of a slowly metabolized carrier. we investigated the pharmacokinetics, efficacy, tolerance and safety of 40 and 50 mg of a new rapidly eliminated depot-form in 61 postpartum women. Bromocriptine rapidly increased after injection and prolactin was effectively suppressed during the study-period of 60 days. Overall efficacy was very good or good in 98% and no rebound lactation occurred. Sixteen women experienced side effects. Tolerance at the injection site was good and safety tests did not show abnormalities. There were no differences between the two dosages. We conclude that this new depot-bromocriptine is a safe, well tolerated and effective drug in the suppression of prolactin and the prevention of post-partum lactation.
J A Kremer, and
R Rolland, and
P F van der Heijden, and
L A Schellekens, and
M B Vosmar, and
I Lancranjan
May 1987,
European journal of obstetrics, gynecology, and reproductive biology,
J A Kremer, and
R Rolland, and
P F van der Heijden, and
L A Schellekens, and
M B Vosmar, and
I Lancranjan
January 1978,
Acta endocrinologica. Supplementum,
J A Kremer, and
R Rolland, and
P F van der Heijden, and
L A Schellekens, and
M B Vosmar, and
I Lancranjan
January 1987,
Acta obstetricia et gynecologica Scandinavica,
J A Kremer, and
R Rolland, and
P F van der Heijden, and
L A Schellekens, and
M B Vosmar, and
I Lancranjan
January 1986,
Obstetrics and gynecology,
J A Kremer, and
R Rolland, and
P F van der Heijden, and
L A Schellekens, and
M B Vosmar, and
I Lancranjan
August 1983,
British journal of obstetrics and gynaecology,
J A Kremer, and
R Rolland, and
P F van der Heijden, and
L A Schellekens, and
M B Vosmar, and
I Lancranjan
October 1984,
British journal of obstetrics and gynaecology,
J A Kremer, and
R Rolland, and
P F van der Heijden, and
L A Schellekens, and
M B Vosmar, and
I Lancranjan
May 1969,
Ginecologia y obstetricia de Mexico,
J A Kremer, and
R Rolland, and
P F van der Heijden, and
L A Schellekens, and
M B Vosmar, and
I Lancranjan
July 1996,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
J A Kremer, and
R Rolland, and
P F van der Heijden, and
L A Schellekens, and
M B Vosmar, and
I Lancranjan
November 1978,
La Nouvelle presse medicale,
J A Kremer, and
R Rolland, and
P F van der Heijden, and
L A Schellekens, and
M B Vosmar, and
I Lancranjan
July 1979,
Archives of gynecology,
