Synthesis and pharmacological activity of 6H-thiazolo [3',2': 1,2]-5-oxopyrimido[5,4-b]indole derivatives, a new heterocyclic ring system. 1990

F Russo, and G Romeo, and S Guccione, and E Bousquet, and A Caruso, and M G Leone, and G Attaguile, and M A Roxas
Institute of Pharmaceutical and Toxicological Chemistry, Faculty of Pharmacy, University of Catania, Italy.

In the outline of the investigations concerning the analgesic and antiinflammatory activity of new fused heterocyclic compounds containing the pyrimidine ring, a series of 6H-thiazolo[3',2': 1,2]-5-oxopyrimido[5,4-b]indole derivatives was synthesized. Pharmacological results are reported and discussed.

UI MeSH Term Description Entries
D007211 Indoles Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
D007928 Lethal Dose 50 The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population. LD50,Dose 50, Lethal
D008297 Male Males
D011597 Psychomotor Performance The coordination of a sensory or ideational (cognitive) process and a motor activity. Perceptual Motor Performance,Sensory Motor Performance,Visual Motor Coordination,Coordination, Visual Motor,Coordinations, Visual Motor,Motor Coordination, Visual,Motor Coordinations, Visual,Motor Performance, Perceptual,Motor Performance, Sensory,Motor Performances, Perceptual,Motor Performances, Sensory,Perceptual Motor Performances,Performance, Perceptual Motor,Performance, Psychomotor,Performance, Sensory Motor,Performances, Perceptual Motor,Performances, Psychomotor,Performances, Sensory Motor,Psychomotor Performances,Sensory Motor Performances,Visual Motor Coordinations
D011743 Pyrimidines A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D002351 Carrageenan A water-soluble extractive mixture of sulfated polysaccharides from RED ALGAE. Chief sources are the Irish moss CHONDRUS CRISPUS (Carrageen), and Gigartina stellata. It is used as a stabilizer, for suspending COCOA in chocolate manufacture, and to clarify BEVERAGES. Carrageenin,iota-Carrageenan,kappa-Carrageenan,lambda-Carrageenan,iota Carrageenan,kappa Carrageenan,lambda Carrageenan
D002621 Chemistry A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004487 Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE. Dropsy,Hydrops,Anasarca

Related Publications

F Russo, and G Romeo, and S Guccione, and E Bousquet, and A Caruso, and M G Leone, and G Attaguile, and M A Roxas
May 1988, Il Farmaco; edizione scientifica,
F Russo, and G Romeo, and S Guccione, and E Bousquet, and A Caruso, and M G Leone, and G Attaguile, and M A Roxas
February 1997, Journal of medicinal chemistry,
F Russo, and G Romeo, and S Guccione, and E Bousquet, and A Caruso, and M G Leone, and G Attaguile, and M A Roxas
August 2001, Die Pharmazie,
F Russo, and G Romeo, and S Guccione, and E Bousquet, and A Caruso, and M G Leone, and G Attaguile, and M A Roxas
April 1997, Farmaco (Societa chimica italiana : 1989),
F Russo, and G Romeo, and S Guccione, and E Bousquet, and A Caruso, and M G Leone, and G Attaguile, and M A Roxas
June 1998, Archives of pharmacal research,
F Russo, and G Romeo, and S Guccione, and E Bousquet, and A Caruso, and M G Leone, and G Attaguile, and M A Roxas
September 2012, Bioorganic & medicinal chemistry,
F Russo, and G Romeo, and S Guccione, and E Bousquet, and A Caruso, and M G Leone, and G Attaguile, and M A Roxas
August 1984, Il Farmaco; edizione scientifica,
F Russo, and G Romeo, and S Guccione, and E Bousquet, and A Caruso, and M G Leone, and G Attaguile, and M A Roxas
March 2009, European journal of medicinal chemistry,
F Russo, and G Romeo, and S Guccione, and E Bousquet, and A Caruso, and M G Leone, and G Attaguile, and M A Roxas
January 2003, Oncology research,
F Russo, and G Romeo, and S Guccione, and E Bousquet, and A Caruso, and M G Leone, and G Attaguile, and M A Roxas
May 1964, Journal of medicinal chemistry,
Copied contents to your clipboard!