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Mapping the functional yeast ABC transporter interactome. 2013
Jamie Snider, and
Asad Hanif, and
Mid Eum Lee, and
Ke Jin, and
Analyn R Yu, and
Chris Graham, and
Matthew Chuk, and
Dunja Damjanovic, and
Marta Wierzbicka, and
Priscilla Tang, and
Dina Balderes, and
Victoria Wong, and
Matthew Jessulat, and
Katelyn D Darowski, and
Bryan-Joseph San Luis, and
Igor Shevelev, and
Stephen L Sturley, and
Charles Boone, and
Jack F Greenblatt, and
Zhaolei Zhang, and
Christian M Paumi, and
Mohan Babu, and
Hay-Oak Park, and
Susan Michaelis, and
Igor Stagljar
Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
ATP-binding cassette (ABC) transporters are a ubiquitous class of integral membrane proteins of immense clinical interest because of their strong association with human disease and pharmacology. To improve our understanding of these proteins, we used membrane yeast two-hybrid technology to map the protein interactome of all of the nonmitochondrial ABC transporters in the model organism Saccharomyces cerevisiae and combined this data with previously reported yeast ABC transporter interactions in the BioGRID database to generate a comprehensive, integrated 'interactome'. We show that ABC transporters physically associate with proteins involved in an unexpectedly diverse range of functions. We specifically examine the importance of the physical interactions of ABC transporters in both the regulation of one another and in the modulation of proteins involved in zinc homeostasis. The interaction network presented here will be a powerful resource for increasing our fundamental understanding of the cellular role and regulation of ABC transporters.
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