Biomaterial Database

Animal models for studying female genital tract infection with Chlamydia trachomatis. 2013

Evelien De Clercq, and Isabelle Kalmar, and Daisy Vanrompay

Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.

Chlamydia trachomatis is a Gram-negative obligate intracellular bacterial pathogen. It is the leading cause of bacterial sexually transmitted disease in the world, with more than 100 million new cases of genital tract infections with C. trachomatis occurring each year. Animal models are indispensable for the study of C. trachomatis infections and the development and evaluation of candidate vaccines. In this paper, the most commonly used animal models to study female genital tract infections with C. trachomatis will be reviewed, namely, the mouse, guinea pig, and nonhuman primate models. Additionally, we will focus on the more recently developed pig model.

UI	MeSH Term	Description	Entries
D002690	Chlamydia Infections	Infections with bacteria of the genus CHLAMYDIA.	Infections, Chlamydia,Chlamydia Infection,Infection, Chlamydia
D002692	Chlamydia trachomatis	Type species of CHLAMYDIA causing a variety of ocular and urogenital diseases.
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005260	Female		Females
D005831	Genital Diseases, Female	Pathological processes involving the female reproductive tract (GENITALIA, FEMALE).	Gynecologic Diseases,Female Genital Diseases,Diseases, Female Genital,Diseases, Gynecologic,Female Genital Disease,Genital Disease, Female,Gynecologic Disease
D005836	Genitalia, Female	The female reproductive organs. The external organs include the VULVA; BARTHOLIN'S GLANDS; and CLITORIS. The internal organs include the VAGINA; UTERUS; OVARY; and FALLOPIAN TUBES.	Accessory Sex Organs, Female,Sex Organs, Accessory, Female,Genital Organs, Female,Genitals, Female,Reproductive System, Female,Female Genital,Female Genital Organ,Female Genital Organs,Female Genitalia,Female Genitals,Female Reproductive System,Female Reproductive Systems,Genital Organ, Female,Genital, Female,Reproductive Systems, Female
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D015231	Sexually Transmitted Diseases, Bacterial	Bacterial diseases transmitted or propagated by sexual conduct.	Venereal Diseases, Bacterial,Bacterial Sexually Transmitted Disease,Bacterial Sexually Transmitted Diseases,Bacterial Venereal Diseases,Sexually Transmitted Disease, Bacterial,Bacterial Venereal Disease,Disease, Bacterial Venereal,Venereal Disease, Bacterial
D060737	Reproductive Tract Infections	Infections of the genital tract in females or males. They can be caused by endogenous, iatrogenic, or sexually transmitted organisms.	Genital Tract Infections,Genital Tract Infection,Infection, Genital Tract,Infection, Reproductive Tract,Infections, Genital Tract,Infections, Reproductive Tract,Reproductive Tract Infection