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The purposes of this study were to determine whether exercise training induces increases in skeletal muscle antioxidant enzymes and to further characterize the relationship between oxidative capacity and antioxidant enzyme levels in skeletal muscle. Male Sprague-Dawley rats were exercise trained (ET) on a treadmill 2 h/day at 32 m/min (8% incline) 5 days/wk or were cage confined (sedentary control, S) for 12 wk. In both S and ET rats, catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPX) activities were directly correlated with the percentages of oxidative fibers in the six skeletal muscle samples studied. Muscles of ET rats had increased oxidative capacity and increased GPX activity compared with the same muscles of S rats. However, SOD activities were not different between ET and S rats, but CAT activities were lower in skeletal muscles of ET rats than in S rats. Exposure to 60 min of ischemia and 60 min of reperfusion (I/R) resulted in decreased GPX and increased CAT activities but had little or no effect on SOD activities in muscles from both S and ET rats. The I/R-induced increase in CAT activity was greater in muscles of ET than in muscles of S rats. Xanthine oxidase (XO), xanthine dehydrogenase (XD), and XO + XD activities after I/R were not related to muscle oxidative capacity and were similar in muscles of ET and S rats. It is concluded that although antioxidant enzyme activities are related to skeletal muscle oxidative capacity, the effects of exercise training on antioxidant enzymes in skeletal muscle cannot be predicted by measured changes in oxidative capacity.
M H Laughlin, and
T Simpson, and
W L Sexton, and
O R Brown, and
J K Smith, and
R J Korthuis
December 2022,
Antioxidants (Basel, Switzerland),
M H Laughlin, and
T Simpson, and
W L Sexton, and
O R Brown, and
J K Smith, and
R J Korthuis
July 1999,
Medicine and science in sports and exercise,
M H Laughlin, and
T Simpson, and
W L Sexton, and
O R Brown, and
J K Smith, and
R J Korthuis
July 2016,
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M H Laughlin, and
T Simpson, and
W L Sexton, and
O R Brown, and
J K Smith, and
R J Korthuis
January 2005,
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M H Laughlin, and
T Simpson, and
W L Sexton, and
O R Brown, and
J K Smith, and
R J Korthuis
July 1992,
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M H Laughlin, and
T Simpson, and
W L Sexton, and
O R Brown, and
J K Smith, and
R J Korthuis
September 1996,
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M H Laughlin, and
T Simpson, and
W L Sexton, and
O R Brown, and
J K Smith, and
R J Korthuis
July 2014,
FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
M H Laughlin, and
T Simpson, and
W L Sexton, and
O R Brown, and
J K Smith, and
R J Korthuis
July 2003,
Free radical biology & medicine,
M H Laughlin, and
T Simpson, and
W L Sexton, and
O R Brown, and
J K Smith, and
R J Korthuis
December 2006,
American journal of physiology. Regulatory, integrative and comparative physiology,
M H Laughlin, and
T Simpson, and
W L Sexton, and
O R Brown, and
J K Smith, and
R J Korthuis
July 2013,
Skeletal muscle,
