BIOMAT Database Logo BIOMAT Database Logo

Staurosporine analogues from microbial and synthetic sources and their biological activities. 2013

B S Park, and A Z Abdel-Azeem, and M M Al-Sanea, and K H Yoo, and J S Tae, and S H Lee
Chemical Kinomics Research Center, Korea Institute of Science and Technology, Seoul 130-650, Republic of Korea.. LSH6211@kist.re.kr.

In 1977 an unknown natural product was isolated from Streptomyces staurosporeus by Omura et al. during a search for new alkaloids present in actinomycetes and was given the name AM-2282. Later, the structure of AM-2282 was elucidated by single crystal X-ray analysis and renamed as staurosporine. It has been published that staurosporine and its analogues display strong inhibitory effect against a variety of kinases and a number of biological properties such as antifungal, antibacterial, and immunosuppressive activities. Despite strong inhibitory activity of staurosporine, a very high level of cross-reactivity makes it impossible to use staurosporine as a therapeutic agent. In the course of searching for other staurosporine-related compounds, a number of staurosporine analogues have been isolated from different microorganisms. In addition, a number of staurosporine analogues have been synthesized to improve the poor selectivity and target specificity of staurosporine which limited its clinical effectiveness. The review addresses staurosporine analogues from both microbial and synthetic sources and their biological activities.

UI MeSH Term Description Entries
D007211 Indoles Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D047428 Protein Kinase Inhibitors Agents that inhibit PROTEIN KINASES. Protein Kinase Inhibitor,Inhibitor, Protein Kinase,Inhibitors, Protein Kinase,Kinase Inhibitor, Protein,Kinase Inhibitors, Protein

Related Publications

B S Park, and A Z Abdel-Azeem, and M M Al-Sanea, and K H Yoo, and J S Tae, and S H Lee
Syntheses, biochemical and biological evaluation of staurosporine analogues from the microbial metabolite rebeccamycin.
September 1998, Bioorganic & medicinal chemistry,
B S Park, and A Z Abdel-Azeem, and M M Al-Sanea, and K H Yoo, and J S Tae, and S H Lee
Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities.
January 2023, Beilstein journal of organic chemistry,
B S Park, and A Z Abdel-Azeem, and M M Al-Sanea, and K H Yoo, and J S Tae, and S H Lee
Irregularly Bridged Epipolythiodioxopiperazines and Related Analogues: Sources, Structures, and Biological Activities.
June 2020, Journal of natural products,
B S Park, and A Z Abdel-Azeem, and M M Al-Sanea, and K H Yoo, and J S Tae, and S H Lee
Biological activities and receptor affinities of some natural and synthetic oestrogens and their D-homo analogues.
October 1978, Experientia,
B S Park, and A Z Abdel-Azeem, and M M Al-Sanea, and K H Yoo, and J S Tae, and S H Lee
Anthraquinones and Their Analogues from Marine-Derived Fungi: Chemistry and Biological Activities.
July 2022, Marine drugs,
B S Park, and A Z Abdel-Azeem, and M M Al-Sanea, and K H Yoo, and J S Tae, and S H Lee
Antimalarial and Antileishmanial Activities of Phytophenolics and Their Synthetic Analogues.
December 2017, Chemistry & biodiversity,
B S Park, and A Z Abdel-Azeem, and M M Al-Sanea, and K H Yoo, and J S Tae, and S H Lee
2-fluoroabscisic acid analogues: their synthesis and biological activities.
January 1999, Journal of agricultural and food chemistry,
B S Park, and A Z Abdel-Azeem, and M M Al-Sanea, and K H Yoo, and J S Tae, and S H Lee
Nordihydroguaiaretic acid analogues: their chemical synthesis and biological activities.
January 2009, Current topics in medicinal chemistry,
B S Park, and A Z Abdel-Azeem, and M M Al-Sanea, and K H Yoo, and J S Tae, and S H Lee
Naturally occurring and synthetic imidazoles: their chemistry and their biological activities.
January 2006, Current medicinal chemistry,
B S Park, and A Z Abdel-Azeem, and M M Al-Sanea, and K H Yoo, and J S Tae, and S H Lee
Biosynthesis, synthetic studies, and biological activities of the jadomycin alkaloids and related analogues.
January 2020, The Alkaloids. Chemistry and biology,
Copied contents to your clipboard!