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A number of phosphoproteins were found in the soluble fraction of rat skeletal muscle by two-dimensional polyacrylamide gel electrophoresis (PAGE). The pattern of some of these phosphoproteins differed in fast (extensor digitorum longus, EDL) or slow (soleus) muscles, was dependent on normal innervation, and was altered with denervation. In order to determine if the pattern was maintained by electrical activity or trophic factors, we compared the effect of electrical block by local neural application of tetrodotoxin with the effect of complete nerve section. Both methods produced similar alterations in phosphoproteins, indicating that the pattern is dependent on nerve activity, not trophic factors. Such phosphoproteins are possible mediators of neural activity on gene expression.
G A Nicholson, and
S Hawkins, and
J G McLeod
May 1995,
The American journal of physiology,
G A Nicholson, and
S Hawkins, and
J G McLeod
December 1980,
Biochemical Society transactions,
G A Nicholson, and
S Hawkins, and
J G McLeod
July 1986,
Experimental neurology,
G A Nicholson, and
S Hawkins, and
J G McLeod
February 1983,
Arkhiv anatomii, gistologii i embriologii,
G A Nicholson, and
S Hawkins, and
J G McLeod
January 1976,
Experimental neurology,
G A Nicholson, and
S Hawkins, and
J G McLeod
July 2002,
Archives of physiology and biochemistry,
G A Nicholson, and
S Hawkins, and
J G McLeod
May 1957,
Endocrinology,
G A Nicholson, and
S Hawkins, and
J G McLeod
February 1979,
Experientia,
G A Nicholson, and
S Hawkins, and
J G McLeod
January 1972,
Physiologia Bohemoslovaca,
G A Nicholson, and
S Hawkins, and
J G McLeod
September 1971,
Nature: New biology,
