BIOMAT Database Logo BIOMAT Database Logo

Fast neutron radiotherapy for primary mucosal melanomas of the head and neck. 2014

Jay J Liao, and Upendra Parvathaneni, and George E Laramore, and John A Thompson, and Shailender Bhatia, and Neal D Futran, and Amit D Bhrany, and Stephen E Hawes, and Matthew Ladra
University of Washington, Department of Radiation Oncology, Seattle, Washington.

BACKGROUND Primary head and neck mucosal melanomas (HNMMs) are rare tumors managed with surgery and/or radiotherapy and associated with poor outcomes. Given their radioresistance, high linear energy transfer radiotherapy with neutrons may improve local control. METHODS We conducted a retrospective review of 14 patients with HNMM treated with neutrons at the University of Washington from 1990 to 2012. Five patients had T3 disease, 9 had T4 disease, 3 had regional nodal disease, and 4 had distant metastases at diagnosis. Primary sites were sinonasal (n=10), lip (n=2), and palate (n=2). Ten patients had initial surgical resection/debulking. RESULTS Nine patients had gross residual disease, 6 had complete response, and 3 had partial response. Local control was achieved in 79% until death or last follow-up, and 50% developed distant metastases. Kaplan-Meier 5-year local control was 66% and overall survival was 21%. CONCLUSIONS High rates of locoregional control were achieved with neutrons, despite the presence of gross disease. Survival was limited by early distant metastases.

UI MeSH Term Description Entries
D008297 Male Males
D008545 Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445) Malignant Melanoma,Malignant Melanomas,Melanoma, Malignant,Melanomas,Melanomas, Malignant
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009092 Mucous Membrane An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa. Lamina Propria,Mucosa,Mucosal Tissue,Muscularis Mucosae,Mucous Membranes,Membrane, Mucous,Membranes, Mucous,Mucosae, Muscularis,Mucosal Tissues,Propria, Lamina,Tissue, Mucosal,Tissues, Mucosal
D005214 Fast Neutrons Neutrons, the energy of which exceeds some arbitrary level, usually around one million electron volts. Fast Neutron,Neutron, Fast,Neutrons, Fast
D005260 Female Females
D006258 Head and Neck Neoplasms Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651) Cancer of Head and Neck,Head Cancer,Head Neoplasm,Head and Neck Cancer,Head and Neck Neoplasm,Neck Cancer,Neck Neoplasm,Neck Neoplasms,Neoplasms, Upper Aerodigestive Tract,UADT Neoplasm,Upper Aerodigestive Tract Neoplasm,Upper Aerodigestive Tract Neoplasms,Cancer of Head,Cancer of Neck,Cancer of the Head,Cancer of the Head and Neck,Cancer of the Neck,Head Neoplasms,Head, Neck Neoplasms,Neoplasms, Head,Neoplasms, Head and Neck,Neoplasms, Neck,UADT Neoplasms,Cancer, Head,Cancer, Neck,Cancers, Head,Cancers, Neck,Head Cancers,Neck Cancers,Neoplasm, Head,Neoplasm, Neck,Neoplasm, UADT,Neoplasms, UADT
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

Jay J Liao, and Upendra Parvathaneni, and George E Laramore, and John A Thompson, and Shailender Bhatia, and Neal D Futran, and Amit D Bhrany, and Stephen E Hawes, and Matthew Ladra
Mucosal melanomas of the head and neck.
October 1977, American journal of surgery,
Jay J Liao, and Upendra Parvathaneni, and George E Laramore, and John A Thompson, and Shailender Bhatia, and Neal D Futran, and Amit D Bhrany, and Stephen E Hawes, and Matthew Ladra
Mucosal melanomas of the head and neck.
January 1975, The Laryngoscope,
Jay J Liao, and Upendra Parvathaneni, and George E Laramore, and John A Thompson, and Shailender Bhatia, and Neal D Futran, and Amit D Bhrany, and Stephen E Hawes, and Matthew Ladra
Mucosal melanomas of the head and neck.
April 1969, The Journal of laryngology and otology,
Jay J Liao, and Upendra Parvathaneni, and George E Laramore, and John A Thompson, and Shailender Bhatia, and Neal D Futran, and Amit D Bhrany, and Stephen E Hawes, and Matthew Ladra
Mucosal melanomas of the head and neck.
July 1998, The Annals of otology, rhinology, and laryngology,
Jay J Liao, and Upendra Parvathaneni, and George E Laramore, and John A Thompson, and Shailender Bhatia, and Neal D Futran, and Amit D Bhrany, and Stephen E Hawes, and Matthew Ladra
Mucosal melanomas of the head and neck.
April 1967, The American journal of roentgenology, radium therapy, and nuclear medicine,
Jay J Liao, and Upendra Parvathaneni, and George E Laramore, and John A Thompson, and Shailender Bhatia, and Neal D Futran, and Amit D Bhrany, and Stephen E Hawes, and Matthew Ladra
[Mucosal melanomas of the head and neck].
June 1988, Nihon Jibiinkoka Gakkai kaiho,
Jay J Liao, and Upendra Parvathaneni, and George E Laramore, and John A Thompson, and Shailender Bhatia, and Neal D Futran, and Amit D Bhrany, and Stephen E Hawes, and Matthew Ladra
Mucosal melanomas of the head and neck.
January 1978, Head & neck surgery,
Jay J Liao, and Upendra Parvathaneni, and George E Laramore, and John A Thompson, and Shailender Bhatia, and Neal D Futran, and Amit D Bhrany, and Stephen E Hawes, and Matthew Ladra
Mucosal melanomas of the head and neck.
August 1986, Otolaryngologic clinics of North America,
Jay J Liao, and Upendra Parvathaneni, and George E Laramore, and John A Thompson, and Shailender Bhatia, and Neal D Futran, and Amit D Bhrany, and Stephen E Hawes, and Matthew Ladra
Postoperative radiotherapy for primary mucosal melanoma of the head and neck.
January 2005, Cancer,
Jay J Liao, and Upendra Parvathaneni, and George E Laramore, and John A Thompson, and Shailender Bhatia, and Neal D Futran, and Amit D Bhrany, and Stephen E Hawes, and Matthew Ladra
[Mucosal malignant melanomas of the head and neck].
February 1999, Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
Copied contents to your clipboard!